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MetabolomicsSerum Metabolomics in the Rat Model of Recurrent Pelvic Pain

This study aimed to investigate systemic metabolic alterations underlying pain-depression comorbidity in the Recurrent Pelvic Pain (RPP) rat model using untargeted serum metabolomics (UPLC-Q-Orbitrap-MS). Comparative analysis revealed distinct metabolic profiles, identifying 234 differential meta...

2026-02-11 | MTBLS13869 | MetaboLights
TranscriptomicsRNA-seq of rat dorsal root ganglia after ligation to investigate central nervous system transcriptomics in chronic pain using agnostic splice site discovery methods
The study pursued dual goals: To advance mRNA-seq bioinformatics towards unbiased transcriptome capture and to demonstrate its potential for discovery in neuroscience by applying the approach to an in vivo model of neurological disease. We found that 12.4% of known genes were induced and 7% were sup...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-20895 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of mouse dorsal root ganglia tissue for six different pain models
Six different mouse pain models were studied: (1) tumour-injection model for bone cancer pain; (2) partial sciatic nerve ligation (PSL) for neuropathic pain; (3) mechanical joint loading for osteoarthritis pain; (4) oxaliplatin-induced painful neuropathy for chemotherapy-induced pain; (5) hyperalges...
ORGANISM(S): Mus musculus 
2018-06-11 | E-MTAB-6864 | biostudies-arrayexpress
MetabolomicsThe effect of an NAT10 inhibitor (remodelin) on inflammation-related genes in the treatment of thalamic hemorrhage based on metabolic data

Thalamic hemorrhage is a disease caused by hemorrhage of the thalamic brain parenchyma and is accompanied by an inflammatory response during development. NAT10 has been associated with a wide range of diseases. The aim of this study was to explore the molecular mechanisms associated with the use ...

2025-11-13 | MTBLS11941 | MetaboLights
ModelsBenson2014 - FAAH inhibitors for the treatment of osteoarthritic pain
Benson2014 - FAAH inhibitors for the treatment of osteoarthritic pain Evaluation of fatty acid amide hydrolase (FAAH) as a target for osteoarthritic pain in humans, using an integrated systems pharmacology model. The SBML version of the model is o...
2024-09-02 | BIOMD0000000512 | BioModels
TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [DRG tissue]
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I...
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51295 | biostudies-arrayexpress
TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [spinal cord tissue]
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I...
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51294 | biostudies-arrayexpress
MetabolomicsUntargeted LC-MS metabolomics profiling of mouse serum following I.v treatment compared with PBS controls
This study investigated serum metabolic alterations associated with I.v treatment in mice. Serum samples from I.v-treated mice and PBS-treated controls were analyzed by untargeted LC-MS metabolomics in both positive and negative ionization modes. The deposited dataset contains mzXML spectral data fr...
2026-09-30 | MTBLS15361 | MetaboLights
ProteomicsEffect of burn wound treatment with fish skin on mouse skin proteome
This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish...
ORGANISM(S): Mus Musculus 
2024-03-11 | PXD050514 | panorama
UnknownCumulative effects of multiple pain sites in youth with chronic pain.
Not available
S-EPMC5995652 | biostudies-literature
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