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ProteomicsPak3 interactors in human cells during starvation
Human Pak3-T421E cDNA with a flag tag was transfected into HEK293 cells using Lipofectomine 2000, After 72 hrs of incubation, PAK3 interactors were pulldwon with FLAG antibody. A sample without PAK3 overexpression was used as a negative control. Changes in PAK3 interactions between basal and starvat...
ORGANISM(S): Homo sapiens (Human) 
2023-05-16 | PXD041986 | Pride
Human Pak3 Lc-ms/ms 
TranscriptomicsLoss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
Over 85% of lung cancer patients harbor overt or subclinical metastases at diagnosis, and therefore most patients die of progressive metastatic disease despite aggressive local and systemic therapies. Somatic mutations in the Smad4 gene have been found in non-small-cell lung cancer, but the underlyi...
ORGANISM(S): Mus musculus 
2021-05-07 | GSE164436 | GEO
UnknownThe p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
Not available
S-EPMC3436265 | biostudies-literature
GenomicsLoss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation
PRJNA690712 | ENA
UnknownLethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.
Not available
S-EPMC4304782 | biostudies-literature
UnknownRestored autophagy is protective against PAK3-induced cardiac dysfunction.
Not available
S-EPMC10265534 | biostudies-literature
UnknownPAK3 promotes the metastasis of hepatocellular carcinoma by regulating EMT process.
Not available
S-EPMC8692680 | biostudies-literature
UnknownPAK3 downregulation induces cognitive impairment following cranial irradiation.
Not available
S-EPMC10746143 | biostudies-literature
UnknownPak3 inhibits local actin filament formation to regulate global cell polarity.
Not available
S-EPMC2714956 | biostudies-literature
UnknownPAK3 pathogenic variant associated with sleep-related hypermotor epilepsy in a family with parental mosaicism.
Not available
S-EPMC12014923 | biostudies-literature
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