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MetabolomicsA Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated im...
2022-01-18 | MTBLS2469 | MetaboLights
MetabolomicsMetabolome and exposome profiling of the biospecimens from COVID-19 patients in India (Nasopharyngeal swab assay)

INTRODUCTION: COVID-19 has become a global impediment by bringing everything to a halt starting from January 2020. India underwent the lockdown starting from 22nd March 2020 with the sudden spike in the number of COVID-19 patients in major cities and states. This study focus...

2022-01-13 | MTBLS2349 | MetaboLights
MetabolomicsMetabolome and exposome profiling of the biospecimens from COVID-19 patients in India (Blood plasma assay)

INTRODUCTION: COVID-19 has become a global impediment by bringing everything to a halt starting from January 2020. India underwent the lockdown starting from 22nd March 2020 with the sudden spike in the number of COVID-19 patients in major cities and states. This study focus...

2022-01-13 | MTBLS2291 | MetaboLights
ProteomicsValidation of proteins showing significant dysregulation from shotgun proteomics experiments in longitudinal plasma samples of COVID-19 patients
A Label Free Quantification study was done to observe the changes in the plasma proteome of patient samples collected at two different time points of disease severity (T1 and T2). A few of the proteins that were significantly dysregulated between the two time points were taken forward for validation...
ORGANISM(S): Homo Sapiens 
PXD026848 | panorama
ProteomicsProteomic Investigation Reveals Dominant Alterations of Neutrophil Degranulation and mRNA Translation Pathways in COVID-19 Patients
The altered molecular proteins and pathways in response to COVID-19 infection are still unclear. Here, we performed a comprehensive proteomics-based investigation of of nasopharyngeal swab samples from COVID-19 patients to identify viral and host peptides by employing simple extraction strategies an...
ORGANISM(S): Homo sapiens (Human) 
2021-02-15 | PXD023016 | Pride
Covid-19 Human Nasopharyngeal swab Sars-cov-2 Mass spectrometry Proteomics 
ProteomicsValidation of detected viral and host peptides from COVID-19 nasopharyngeal swab samples
In the current scenario of COVID-19, an assay that can efficiently and specifically detect infection by SARS-COV2 is required. Nasopharyngeal swabs are non-invasive samples and can be conveniently acquired from the population to be screened. In this work, we have validated a few viral and host pepti...
ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2 
2021-04-02 | PXD021845 | panorama
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