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UnknownThe ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells.
Not available
S-EPMC2572695 | biostudies-literature
UnknownComplex G-protein signaling of the adhesion GPCR, ADGRA3.
Not available
S-EPMC12059339 | biostudies-literature
UnknownIs it feasible to perform permanent left bundle branch area pacing, guided only by an electroanatomical mapping system? Proposal of a zero-fluoroscopy approach.
Not available
S-EPMC9039091 | biostudies-literature
ProteomicsProteomic analysis of cerebrospinal fluid of amyotrophic lateral sclerosis patients in the presence of autologous bone marrow derived mesenchymal stem cells
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressive motoneuron degenerative disorder. There are still no drugs capable of slowing disease evolution or improving life quality of ALS patients. Thus, autologous stem cell therapy has emerged as an alternative treatment regime to be in...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD053129 | Pride
Mesenchymal stem cells Cerebrospinal fluid Amyotrophic lateral sclerosis Proteomics 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part3
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003820 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part2
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003819 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
UnknownAggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.
Not available
S-EPMC6355082 | biostudies-literature
ProteomicsProteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix
Trypomastigotes from Trypanosoma cruzi adhere to the extracellular matrix (ECM) in order to invade mammalian host cells. Incubation of trypomastigotes with ECM leads to a decrease of nitric oxide synthase (NOS) activity and associated post-translational modifications (PTMs). Herein, resin-assisted e...
ORGANISM(S): Trypanosoma cruzi 
2020-10-27 | PXD018275 | Pride
Post-translational modifications Nitric oxide synthase Histones S-nitrosylation Proteomic Trypanosoma cruzi 
ProteomicsExtracellular matrix proteome remodelling in human glioblastoma and medulloblastoma
Medulloblastomas (MBs) and Glioblastomas (GBMs) are high-incidence central nervous system tumors. Different origin sites and changes in the tissue microenvironment have been associated with onset and progression. Here, we describe differences between the ECM signature of these tumors. We compared th...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD023350 | Pride
Glioblastoma Medulloblastoma Proteomics Extracellular matrix Fibronectin 
UnknownOn the species status of the root-knot nematode Meloidogyne ulmi Palmisano & Ambrogioni, 2000 (Nematoda, Meloidogynidae).
Not available
S-EPMC3867104 | biostudies-literature
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