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ProteomicsN-glycosylated LTβR increases the Th17/Treg cell ratio in liver cancer by blocking RORC ubiquitination and FOXP3 transcription
Proteins binding to PELI1 and TRAF3 were identified by protein profiling
ORGANISM(S): Mus Musculus 
2025-04-08 | PXD062760 |
ProteomicsNew mechanistic understanding of FXR agonist Vonafexor: inducing sublethal damage of HBV-positive liver cancer cells via promoting anti-tumor immunity
To elucidate the mechanism by which Vonafexor enhanced T and NK cell function, we conducted a proteomic analysis of immune cells derived from HBV-positive HCC following stimulation with Vonafexor.
ORGANISM(S): Homo Sapiens 
2025-04-08 | PXD062758 |
ProteomicsIL-33 stabilizes the transcription factor IRF1
Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in tumor growth and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that its nuclear function mediated a mechanism of immune escape.
ORGANISM(S): Homo Sapiens 
2022-12-28 | PXD039110 |
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