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ProteomicsThe proteomics of mice granulosa cells
In this study, the samples were subjected to quantitative proteomic studies through the application of a series of cutting-edge techniques, including protein extraction, enzyme digestion, liquid chromatography-mass spectrometry tandem analysis, and bioinformatic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD059159 | Pride
Mice，proteomics，lc-ms/ms 
ProteomicsThe lactylome of mice granulosa cells
Follicular GCs were obtained through intraperitoneal injections of 10, 5, 2, and 2 IU FSH at 12 h intervals. For the enrichment of Kla-modified peptides, the tryptic peptides were solubilized in NETN buffer (1 mM EDTA, 50 mM Tris–HCl, 100 mM NaCl, 0.5% NP-40, pH 8.0) and then incubated with prewashe...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD059168 | Pride
The lactylome of mice granulosa cells 
MetabolomicsIntra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes
In this study we explored a unique cohort of 43 samples to build a map of metabolites varying in T2D across five different tissues (subcutaneous adipose tissue, liver, pancreatic islets, skeletal muscle and blood serum). The samples originate from the Excellence in Diabetes biobank (EXODIAB) in Swed...
2018-10-08 | MTBLS690 | MetaboLights
MetabolomicsIntegration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...
2020-01-06 | MTBLS1051 | MetaboLights
UnknownIntegrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models.
Not available
S-EPMC11955770 | biostudies-literature
UnknownMoisture as a key factor alleviating low-temperature stress: Effects of hydrothermal conditions on maize emergence
Not available
S-EPMC12928403 | biostudies-literature
TranscriptomicsMapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Insulin (INS) synthesis and secretion from pancreatic M-NM-2 cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb ...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-25862 | biostudies-arrayexpress
UnknownGout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators.
Not available
S-EPMC11920238 | biostudies-literature
UnknownP300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth.
Not available
S-EPMC4924775 | biostudies-literature
UnknownYAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6.
Not available
S-EPMC6014930 | biostudies-literature
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