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MetabolomicsIntegrated Multi-omics Elucidation of the Uric Acid Degradation Pathway in Limosilactobacillus fermentum M5e

Hyperuricemia is a growing global health concern associated with gout, renal diseases, and cardiovascular disorders. Current pharmacotherapies are often limited by side effects, underscoring the need for alternative strategies. In this study, we isolated Limosilactobacillus fermentum M5...

2026-01-26 | MTBLS13223 | MetaboLights
TranscriptomicsThe pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii
The human gut microbiota harbors methanogens represented by the dominant archaeon, Methanobrevibacter smithii, a polyphyletic group of acetogens, and sulfate-reducing bacteria. Defining their roles in the H2-economy of the gut has potential therapeutic importance for modulating the efficiency of fe...
ORGANISM(S): Methanobrevibacter smithii 
2011-03-30 | E-GEOD-25408 | biostudies-arrayexpress
TranscriptomicsProbing the pan genome of a foodborne bacterial pathogen Listeria monocytogenes
Full title: Probing the pan genome of a foodborne bacterial pathogen Listeria monocytogenes: Implications for its niche adaptation, pathogenesis, and evolution Listeria monocytogenes is a foodborne bacterial pathogen well known for adaptability to diverse environmental and host niches, and a high f...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-04-06 | E-GEOD-20367 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by the pan-PIM inhibitor ETP-39010 in 4 peripheral T cell lymphoma cell lines
Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. In these study we hypothesized that PIM kinases could be of therapeutic value in PTCL because we ...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-42595 | biostudies-arrayexpress
TranscriptomicsMethanobrevibacter smithii expression profiling
This SuperSeries is composed of the following subset Series: GSE25408: The pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii GSE25535: Expression data from an in vitro growth of Methanobrevibacter smithii PS Refer to individual Series
ORGANISM(S): Methanobrevibacter smithii ATCC 35061 
2011-11-07 | E-GEOD-25537 | biostudies-arrayexpress
TranscriptomicsRNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass and molecular pathway cancer diagnostics
We report RNA-sequencing data of 283 blood platelet samples, including 228 tumor-educated platelet (TEP) samples collected from patients with six different malignant tumors (non-small cell lung cancer, colorectal cancer, pancreatic cancer, glioblastoma, breast cancer and hepatobiliary carcinomas). I...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-68086 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Pan troglodytes with chronic hepatitis C virus infection following therapeutic silencing of microRNA-122 using SPC3649
Chimpanzees with chronic Hepatitis C infection treated with LNA-antimiR-122.
ORGANISM(S): Pan troglodytes 
2010-10-01 | E-MEXP-2375 | biostudies-arrayexpress
TranscriptomicsDepletion of Erk1 and Erk2 MAP kinases in primary human keratinocytes
We assessed the effect of RNAi-mediated MAP kinase cascade signaling blockade in primary human keratinocytes. Two sets of siRNA targeting different regions of the Erk1/2 genes were used, enabling identification of off-target siRNA effects. Primary human keratinocytes were electroporated with scra...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-15417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of M and S molecular forms of Anopheles gambiae at each of three developmental stages
We examined patterns of gene expression in two independent colonies of both M and S molecular forms of Anopheles gambiae at each of three developmental stages of interest: late larvae, sugar-fed virgin females, and gravid females. For each colony, replicates were derived from independent RNA samples...
ORGANISM(S): Anopheles gambiae 
2008-07-10 | E-TABM-344 | biostudies-arrayexpress
TranscriptomicsCharacterization of probiotic Escherichia coli isolates using a novel pangenome microarray
Background: Based on 32 Escherichia coli and Shigella genome sequences, we have developed an E. coli pan-genome microarray. Publicly available genomes were annotated in a consistent manor to define all currently known genes potentially present in the species. The chip design was evaluated by hybridi...
ORGANISM(S): Escherichia coli 
2010-05-26 | E-GEOD-8595 | biostudies-arrayexpress
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