Sort   by:  
 Page size 
TranscriptomicsPrimary cilium-autophagy-Nrf2 (PAN) axis links the cell cycle to neuroectoderm fate in human embryonic stem cells
Under defined differentiation conditions human embryonic stem cells (hESCs) can be directed toward a mesendodermal (ME) or neuroectoderm (NE) fate, the first decision during hESC differentiation. Coupled with G1 lengthening a divergent ciliation pattern emerged within the first 24 hours of induced l...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-69982 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression change in the cerebellum of Niemann-Pick disease type C mice with deletion of Ccl3 or Purkinje neuron-specific NPC1 rescue
Macrophage inflammatory protein 1alpha/CCL3 protein is a known pro-inflammatory cytokine that can mediate chemotaxis of monocytes and promote cell degranulation. Ccl3 gene expression is elevated in the CNS and visceral tissue of many lysosomal storage disorders. The deletion of Ccl3 in a mouse model...
ORGANISM(S): Mus musculus 
2012-04-16 | E-GEOD-36119 | biostudies-arrayexpress
ProteomicsDiscovery of covalent CDK14 inhibitors with pan-TAIRE family specificity
Cyclin dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15-18) are proteins that lack functional annotation but are frequent off-targets of clinical kinase inhibitors. In this study we develop and characterize FMF-04-159-2, the first tool compound that specifically targets CDK14 cova...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD012692 | Pride
Covalent inhibitor Druggable genome Mitosis Taire kinase Cell-cycle Cdk14 
GenomicsWhole-genome nucleosome mapping in meiotic diploid S. cerevisiae
We determined nucleosome positions throughout the genome in diploid S. cerevisiae undergoing early stages of synchronous meiosis. This study sought to assess if systematic reorganization of nucleosomes occurs during meiotic prophase at or near sites of DNA double strand break formation. Six samples ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26452 | biostudies-arrayexpress
GenomicsGenome-wide mapping of meiotic double-strand breaks by sequencing Spo11 oligos.
The nonrandom distribution of meiotic recombination shapes patterns of inheritance and genome evolution, but chromosomal features governing this distribution are poorly understood. Formation of the DNA double-strand breaks (DSBs) that initiate recombination results in accumulation of Spo11 protei...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26449 | biostudies-arrayexpress
ProteomicsMass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancer

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, et al., Cancer Res. 2018 May 15;78(10):2732-2746. doi: 10.1158/0008-5472.CAN-17-1990.

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently obs...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-19 | MSV000083050 | MassIVE
GenomicsMCM KC-167 ChIP-Seq experiment
modENCODE_submission_2783 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We will precisely identify sequence elements that direct DNA replication by using chromatin immunoprecipitation of known ...
ORGANISM(S): Drosophila melanogaster 
2010-03-16 | E-GEOD-20890 | biostudies-arrayexpress
UnknownPan-cancer analysis of whole genomes.
Not available
S-EPMC7025898 | biostudies-literature
UnknownDiscovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Not available
S-EPMC9228641 | biostudies-literature
TranscriptomicsComparative genomic hybridization of samples from 30 humans and 30 chimpanzees to survey copy number variation in these species
Sixty-one array-CGH experiments were performed on the human WGTP platform, comparing: (1) 30 unrelated chimpanzees to a single chimpanzee reference individual, (2) 30 unrelated humans to a single human reference individual and (3) the chimpanzee reference individual to the human reference individual...
ORGANISM(S): Pan troglodytes 
2008-08-28 | E-TABM-479 | biostudies-arrayexpress
Sort   by:  
 Page size