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TranscriptomicsEffect of simvastatin on pancreatic cancer cells
The aim of our study was to assess the impact of simvastatin on the amount of cytosolic lipid droplets (LDs), which are implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. Human pancreatic cancer cells MiaPaCa-2 were t...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-MTAB-1501 | biostudies-arrayexpress
TranscriptomicsA GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which is an indolent and slow-growing pancreatic neoplasm that secretes abundant mucin. GNAS mutation is not observed in conventional ductal adenocarcinomas of the pa...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53350 | biostudies-arrayexpress
TranscriptomicsAltering cancer transcriptomes using epigenomic inhibitors [RNA-Seq]
We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. We found that both drugs cause large-scale changes in the transcriptome o...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-63776 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of autophagy proficient and compromised cell lines, determined by expression levels of Atg5
Autophagy is activated in pancreatic ductal adenocarcinoma (PDAC) and is currently being considered a promising therapeutic target in clinical trials. PDAC is a highly lethal disease with incidence rate equalling mortality rate. Main reasons for PDAC lethality are late-stage diagnosis, high agressiv...
ORGANISM(S): Mus musculus 
2018-10-15 | E-MTAB-6275 | biostudies-arrayexpress
TranscriptomicsGenome wide analysis of pancreatic gene expression by Interleukin 1M-NM-2 in human epithelial pancreatic Mia Paca-2 cells.
Analysis of the pancreatic gene expression with IL-1M-NM-2 stimulation. Components of the integrin pathway were significantly altered with IL-1M-NM-2 which play critical role in the execution of apoptosis.The results revealed several important cellular pathways and the biological processes of the ge...
ORGANISM(S): Homo sapiens 
2012-06-20 | E-GEOD-26702 | biostudies-arrayexpress
TranscriptomicsSphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet B-cell Endoplasmic Reticulum Stress and Proliferation
Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that regulates basic cell functions through metabolic and signaling pathways. Intracellular metabolism of S1P is controlled, in part, by two homologous S1P phosphatases, 1 and 2, which are encoded by Sgpp1 and Sgpp2, respectively. S1P phosph...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-73131 | biostudies-arrayexpress
ProteomicsThe combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
Exosomes from pancreatic cancer-associated fibroblasts and mesenchymal stem cells that have been transduced with the yeast cytosine deaminase::uracil phosphoribosyl transferase release suicide gene exosomes acting as "Trojan horse" drugs, effectively killing pancreatic cancer cells by converting the...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD059055 | Pride
Pancreatic cancer-associated fibroblasts Mesenchymal stem cells Gene-directed enzyme prodrug therapy Pancreatic cancer intracellular treatment Suicide gene exosomes 
TranscriptomicsTranscription profiling of mouse islet growth after partial pancreatectomy and exendin-4 Treatment
Diabetes mellitus results from an inadequately functioning beta-cell mass. In the adult pancreas, beta-cell mass is dynamic, increasing to meet metabolic demands and decreasing with metabolic or injury insults. Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor agonist that augments beta-cell m...
ORGANISM(S): Mus musculus 
2005-12-01 | E-CBIL-5 | biostudies-arrayexpress
ProteomicsGlyceraldehyde treatment on pancreatic ductal epithelial cells
To study the impact of the accumulation of glyceraldehyde-derived intracellular protein advanced glycation end products (AGEs) on global proteomic changes in pancreatic ductal epithelial cells. The cells were treated with glyceraldehyde for up to 2 days and changes of protein expressions were assess...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD050491 | Pride
Glycation Glyceraldehyde Advanced glcation end products (ages) Epethelial cells 
TranscriptomicsmiR-196a is able to restore the aggressive phenotype of Annexin A1 CRISPR/Cas9 knock-out pancreatic cancer cells
Annexin A1 (ANXA1) is a Ca2+-binding protein involved in pancreatic cancer (PC) progression. It is able to mediate cytoskeletal organization maintaining a malignant phenotype. ANXA1 Knock-Out (KO) MIA PaCa-2 cells partially lost their migratory and invasive capabilities and also the metastatization ...
ORGANISM(S): Homo sapiens 
2018-08-31 | E-MTAB-6599 | biostudies-arrayexpress
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