Sort   by:  
 Page size 
MetabolomicsMetabolome profiling on resectable pancreatic ductal adenocarcinoma patients with early liver metastasis
Pancreatic ductal adenocarcinoma (PDAC) remains difficult to cure because many patients develop liver metastasis even after apparently curative resection. Bile is in close contact with the pancreatobiliary system, but its multi-omic features in resectable PDAC and their relationship to postoperative...
2026-10-17 | MTBLS15948 | MetaboLights
Metabolomics1H-NMR metabolomics identifies hypoxanthine as a novel metastasis-associated metabolite
Breast cancer is one of the leading causes of death in females, mainly because of metastasis. Oncometabolites, produced via metabolic reprogramming, can influence metastatic signaling cascades. Accordingly, and based on our previous results, we hypothesized that metabolites from highly metastatic br...
2025-09-19 | MTBLS7764 | MetaboLights
MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
MetabolomicsHyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid, yet the key molecular regulators remain undefined. Here, we reveal that early disseminated OC cells are ingeniously utilize hyaluronic aci...
2026-07-10 | MTBLS15007 | MetaboLights
MetabolomicsMutations-Upstream-of-Metabolomic-Signature Based Functional Analyses Identify Prognostic Biomarkers and Therapeutic Targets in Pancreatic Ductal Adenocarcinoma

Cross-talk among downstream regulatory networks of genome mutations has been the major hypothetical mechanism underlying poor prognosis and low-responsive rates for targeted therapy of pancreatic ductal adenocarcinoma (PDAC). By applying a causal inference-based mutation-upstream-of-the-metabolom...

2025-10-13 | MTBLS13111 | MetaboLights
ProteomicsLoss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis
Here we utilized a mouse model of PDAC and human pancreatic cancer cell lines to investigate the role of HIF1alpha in pancreatic cancer. Contrary to the conventional notion that HIF1alpha plays a tumor promoting role in several cancers, our findings indicate a tumor suppressive role of HIF1alpha in ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-21 | MSV000084223 | MassIVE
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis
Not available
ORGANISM(S): Mus musculus 
ST002489 | MetabolomicsWorkbench
TranscriptomicsMultiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficie...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-14245 | biostudies-arrayexpress
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - human plasma metabolomics
Not available
ORGANISM(S): Homo sapiens 
ST002490 | MetabolomicsWorkbench
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse serum metabolomics
Not available
ORGANISM(S): Mus musculus 
ST002485 | MetabolomicsWorkbench
Sort   by:  
 Page size