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TranscriptomicsTranscription profiling by array of cancer associated fibroblasts from pancreatic ductal adenocarcinoma in comparison to normal dermal fibroblasts
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor type with extremely high mortality (up to 92%) during 5 years after diagnosis. Here, cancer associated fibroblasts (CAF) from PDAC were compared to CAF from melanoma metastases (MELF) and to normal dermal fibroblasts (DF). The analysis w...
ORGANISM(S): Homo sapiens 
2021-11-01 | E-MTAB-8764 | biostudies-arrayexpress
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic (KPC-Brca1) cancer-associated fibroblasts (CAFs)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42364 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human primary pancreatic cancer cells and cancer associated fibroblasts co-cultured to study the cross talk between these cells
Coculture of primary pancreatic cancer cells and cancer associated fibroblasts (CAF) in vitro to study the cross talk between these cells
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2826 | biostudies-arrayexpress
ProteomicsFAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Cancer-associated fibroblasts (CAFs), although considered as the most abundant pancreatic ductal adenocarcinoma (PDAC) stromal cells playing a critical role in tumor progression and chemoresistance, are not yet directly druggable. Here we report that focal adhesion kinase (FAK) activity (evaluated b...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD018899 | Pride
Fak Cancer-associated fibroblasts Pancreatic cancer Extracellular matrix 
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
GenomicsFunctional heterogeneity of cancer-associated fibroblasts in pancreatic cancer
Functional heterogeneity of cancer-associated fibroblasts in pancreatic cancer
PRJNA816929 | ENA
TranscriptomicsGene expression analysis of pancreatic cancer associated fibroblasts
Gene expression analysis of pancreatic cancer associated fibroblasts and control fibroblasts To identify signaling pathways important in tumor-stromal cell interactions, we performed gene expression profiling on pancreatic cancer associated fibroblast cultures and control fibroblast cultures using A...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-21440 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of 5-aza-dC treated pancreatic cancer associated fibroblasts
Gene expression analysis of 5-aza-dC treated pancreatic cancer associated fibroblasts To identify genes silenced by methylation in pancreatic CAFs, we performed gene expression profiling on 5-aza-dC treated pancreatic cancer associated fibroblast cultures using Affymetrix Exon arrays. We analyzed 5 ...
ORGANISM(S): Homo sapiens 
2010-11-20 | E-GEOD-20911 | biostudies-arrayexpress
GenomicsTriptolide Targets Super-Enhancer Networks in Pancreatic Cancer Cells and Cancer Associated Fibroblasts
Triptolide Targets Super-Enhancer Networks in Pancreatic Cancer Cells and Cancer Associated Fibroblasts
PRJNA663345 | ENA
ProteomicsSecretome of cancer-associated fibroblasts (CAFs) influences drug sensitivity in cancer cells
Resistance is a major problem with effective cancer treatment and the stroma forms a significant portion of the tumor mass but traditional drug screens involve cancer cells alone. Cancer-associated fibroblasts (CAFs) are a major tumor stroma component and its secreted proteins may influence the func...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD048307 | Pride
Cancer-associated fibroblasts Caf Secretome 
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