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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
TranscriptomicsGene expression profile of microdissected mucinous cystic neoplasms of the pancreas
Gene expression profile of laser-capture microdissected epithelium component of 6 mucinous cystic neoplasms of the pancreas were included in the study. The expression arrays were generated with Affymetrix HU133A gene chips (18,462 genes/EST transcripts).
ORGANISM(S): Homo sapiens 
2018-06-28 | E-MTAB-6853 | biostudies-arrayexpress
ProteomicsProteomic profiling of pancreatic cyst fluid in patients with pancreatic cystic lesions identifies novel biomarkers of pancreatic cancer risk
Pancreatic Cancer (PC) has the worst 5-year survival rate of any cancer as of 2024, at just 13%. The late-stage diagnosis of these patients limits their treatment options, further compounding the problem. Early detection of PC, therefore, is the primary concern of most PC research, as it has the pot...
ORGANISM(S): Homo sapiens (Human) 
2025-01-06 | PXD057299 | Pride
Human Pancreatic cystic lesions Lc-ms Risk Pancreatic cancer Proteomics Pancreatic cyst fluid Biomarkers 
ProteomicsProteomic profiling of serum in patients with pancreatic cystic lesions identifies novel biomarkers of pancreatic cancer risk
Pancreatic Cancer (PC) has the worst 5-year survival rate of any cancer as of 2024, at just 13%. The late-stage diagnosis of these patients limits their treatment options, further compounding the problem. Early detection of PC, therefore, is the primary concern of most PC research, as it has the pot...
ORGANISM(S): Homo sapiens (Human) 
2025-01-06 | PXD057661 | Pride
Human Pancreatic Serum Lc-ms Risk Pancreatic cancer Cystic lesions Proteomics Biomarkers 
ProteomicsQuantitative Proteomic Profiling for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasm using Pancreatic Cyst Fluid
The increased number of pancreatic cyst lesions (PCLs) have been detected through the development of abdominal imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS). However, accurate classification of cystic lesions is difficult beca...
ORGANISM(S): Homo sapiens (Human) 
2020-09-06 | PXD016127 | Pride
Mucinous cystic neoplasm (mcn) Pancreatic cyst fluid Biomarkers Intraductal papillary mucinous neoplasm (ipmn) Serous cystic neoplasm (scn) Lc-ms/ms 
TranscriptomicsmiRNA expression profiles in Pancreatic Cystic tumours and Pancreatic Cancer
MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with premalignant lesions. We wished to identify miRNA expression profiles in pancreatic cystic tumors with low malignant potential (serous microcystic adenomas) and ...
ORGANISM(S): Homo sapiens 
2011-05-18 | E-GEOD-29352 | biostudies-arrayexpress
UnknownEUS-guided through-the-needle biopsy for pancreatic cystic lesions.
Not available
S-EPMC6731357 | biostudies-literature
GenomicsmiRNA expression profiles in Pancreatic Cystic tumours and Pancreatic Cancer
MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with premalignant lesions. We wished to identify miRNA expression profiles in pancreatic cystic tumors with low malignant potential (serous microcystic adenomas) and ...
ORGANISM(S): Homo sapiens 
2011-05-18 | GSE29352 | GEO
UnknownFrequent detection of pancreatic lesions in asymptomatic high-risk individuals.
Not available
S-EPMC3321068 | biostudies-literature
UnknownGNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling.
Not available
S-EPMC6219919 | biostudies-literature
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