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ProteomicsProteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids
Extracellular vesicles (EVs) are produced and released by both healthy and malignant cells and bear markers indicative of ongoing biological processes. In the present study we utilized high resolution flow cytometry to detect EVs in the plasma of patients with pancreatic ductal adenocarcinoma (PDAC)...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030325 | Pride
Ev markers Mass spectrometry Extracellular vesicles High resolution flow cytometry Biomarkers Pdac Pancreatic ductal adenocarcinoma 
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057829 | Pride
Murine pancreatic exocrine organoids 
ProteomicsProteomics on pancreatic ductal organoids
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and model disease like pancreatitis and pancreatic cancer. Yet, donor material availability, genetic variability and a lack of extensive benchmarking to healthy and disease pancreas limits the range of...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2025-11-10 | PXD068063 | Pride
Pancreatic ductal organoids  porcine pancreas  chemical screen  cross-species comparison  scrna-seq profile  proteome profile 
TranscriptomicsPancreatic cancer organoid
Organoids from KPC pancreatic tumor tissue was treated with growth medium or conditional medium of mast cells treated with WT or BAG6 KO EVS of Pan02.
ORGANISM(S): Mus musculus 
2024-12-31 | E-MTAB-13570 | biostudies-arrayexpress
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057888 | Pride
Murine pdac organoids 
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD057928 | Pride
Human pdac organoids 
ProteomicsModelling Plasticity and Dysplasia of Pancreatic Ductal Organoids Derived from Human Pluripotent Stem Cells
Full protein measurements from in vitro differentiation of the human embryonic stem cell line HUES8 into pancreatic progenitors (PP) and pancreatic duct-like organoids (PDLOs). Protein intensities were quantified by mass spectrometry analysis from PPs at day 13 and from PDLOs at day 59. Please see r...
ORGANISM(S): Homo sapiens (Human) 
2021-03-19 | PXD018785 | Pride
Organoids Ductal organoids Pancreas 
GenomicsExpression Analysis of Mouse Tumor and Metastatic Pancreatic Ductal Adenocarcinoma Organoids
Expression Analysis of Mouse Tumor and Metastatic Pancreatic Ductal Adenocarcinoma Organoids
PRJNA597074 | ENA
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057798 | Pride
Murine normal pancreatic tissue 
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