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ProteomicsiTRAQ-based analysis of muscle mitochondria isolated from LONP1-mKO mice
This experiment was conducted to identify the mitochondrial protein changes in the presence and absence of LONP1 in skeletal muscle. The following abstract from the submitted manuscript describes the major findings of this work.Disuse-associated loss of muscle LONP1 impairs mitochondrial quality and...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-05 | PXD029722 | Pride
Mouse Skeletal muscle 
ProteomicsURI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers. HEK293T cells were transfected with His-URI plasmid before anti-His immunoprecipitation and gel cutting. LC-MS/MS was performed to identify URI potential binding proteins.
URI keeps low levels of p53 in a TRIM28-MDM2 dependent manner, maintains SCD1 activity and accumulation of MUFAs, and subsequently promotes resistance to TKIs in cancer cell. URI-p53-SCD1 axis mediates resistance of TKIs and may explain why p53-wild type HCC still showed intrinsic resistance to TKIs...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD045407 | Pride
Uri 
ProteomicsChronic Stress Induced and Tumor Derived SP1+ exosomes Polarizing IL-1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer
We collected tumor-derived exosomes of 4T1 tumor-bearing mice in the control group and the stress group.
ORGANISM(S): Mus Musculus 
2023-12-26 | PXD048125 |
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