Pangas Stephanie A SA

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pride (2)
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2015 (1)
2026 (1)
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Transcription profiling by array (1)

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Baylor College of Medicine, Houston, Texas, USA (1)
Pathology, Baylor College of Medicine, Houston, TX 77030 (1)

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Profiling postnatal folliculogenesis in ovaries with loss of oocyte SUMOylation

SUMOylation plays a critical role in regulating protein function. In the ovary, disrupting expression of the E2 SUMO conjugation enzyme in mouse oocytes beginning at the primordial follicle stage results in female sterility and loss of the ovarian reserve in early adulthood. To determine how follicu...

ORGANISM(S): Mus musculus (Mouse)

2025-05-07 | PXD055913 | Pride

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development

The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...

ORGANISM(S): Mus musculus

2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress

NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription

As women age, their oocytes decline in both quantity and quality, leading to eventual infertility. Part of this decline is associated with increased levels of reactive oxygen species and decreased mitochondrial function, which are associated with lower live birth rates. However, detailed mechanisms ...