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UnknownThe role of gender in a smoking cessation intervention: a cluster randomized clinical trial.

Background

The prevalence of smoking in Spain is high in both men and women. The aim of our study was to evaluate the role of gender in the effectiveness of a specific smoking cessation intervention conducted in Spain.

Methods

This study was a secondary analysis of a cluster randomize...
S-EPMC3125366 | biostudies-literature
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.

Importance

Rheumatic heart disease (RHD) remains a public health issue in low- and middle-income countries (LMICs). However, there are few large studies enrolling individuals from multiple endemic countries.

Objective

To assess the risk and predictors of major patient-important clinic...
S-EPMC11154374 | biostudies-literature
UnknownEffect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial.

Importance

There is limited evidence on the benefits of sacubitril/valsartan vs broader renin angiotensin system inhibitor background therapy on surrogate outcome markers, 6-minute walk distance, and quality of life in patients with heart failure and mildly reduced or preserved left ventricu...
S-EPMC8596197 | biostudies-literature
UnknownGlobal attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study.

Background

Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to append...
S-EPMC7675377 | biostudies-literature
UnknownThe Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography.

Background and objectives

Contrast-associated AKI may result in higher morbidity and mortality. Intravenous fluid administration remains the mainstay for prevention. There is a lack of consensus on the optimal administration strategy. We studied the association of periprocedure fluid adminis...
S-EPMC9528263 | biostudies-literature
UnknownGlobal disparities in surgeons' workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study.
The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questi...
S-EPMC11455666 | biostudies-literature
UnknownA pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan.

Background

Approximately 1 in 10 patients with a surgically treated open fracture will develop a surgical site infection. The Aqueous-PREP trial will investigate the effect of 10% povidone-iodine versus 4% chlorhexidine in aqueous antiseptic solutions in reducing infections after open fractu...
S-EPMC9465853 | biostudies-literature
UnknownEffectiveness of a stepped primary care smoking cessation intervention (ISTAPS study): design of a cluster randomised trial.

Background

There is a considerable body of evidence on the effectiveness of specific interventions in individuals who wish to quit smoking. However, there are no large-scale studies testing the whole range of interventions currently recommended for helping people to give up smoking; specific...
S-EPMC2666720 | biostudies-literature
UnknownAssociation of COVID-19 With Achieving Time-to-Surgery Benchmarks in Patients With Musculoskeletal Trauma.

Importance

In response to the COVID-19 pandemic, many hospital systems were forced to reduce operating room capacity and reallocate resources. The outcomes of these policies on the care of injured patients and the maintenance of emergency services have not been adequately reported.

Object...

S-EPMC8727030 | biostudies-literature
UnknownIncidence and diagnosis of ventilator-associated tracheobronchitis in the intensive care unit: an international online survey.

Introduction

Several aspects of ventilator-associated tracheobronchitis (VAT)-including diagnostic criteria, overlap with ventilator-associated pneumonia (VAP), and appropriate treatment regimens-remain poorly defined. The objectives of this study were to survey reported practices in the cli...
S-EPMC4057509 | biostudies-literature
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