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TranscriptomicsTranscription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse keratinocytes in embryos and newborns, and Notch1 expression in newborns
Comparison between pattern of gene expression in uncultured keratinocytes derived from the epidermis of embryonic mice (E15.5) versus newborn mice and comparison between pattern of gene expression in primary keratinocytes derived from newborn mice plus/minus activated Notch1 expression.
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1569 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse keratinocytes infected with AD and Ad-NotchIC viruses reveals cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 a...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5229 | biostudies-arrayexpress
ProteomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation
Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of the tumor stroma. Here we show that loss of androgen receptor (AR), which trigg...
ORGANISM(S): Homo sapiens (Human) 
2024-08-12 | PXD042059 | Pride
Human Cancer-associated fibroblasts Androgen receptor 
UnknownThe ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome.
Not available
S-EPMC9935893 | biostudies-literature
UnknownNuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation.
Not available
S-EPMC11392952 | biostudies-literature
UnknownTuning the surface functionality of polyethylene glycol-modified graphene oxide/chitosan composite for efficient removal of dye.
Not available
S-EPMC10439132 | biostudies-literature
UnknownCSL controls telomere maintenance and genome stability in human dermal fibroblasts.
Not available
S-EPMC6715699 | biostudies-literature
TranscriptomicsPhysical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution [RNA-seq]
Senescence of stromal fibroblasts has been linked to establishment of cancer associated fibroblasts (CAF) and aging-associated increase of tumors. However, in clinically occurring carcinomas, density and proliferation of CAFs are frequently increased rather than decreased. We previously showed that ...
ORGANISM(S): Homo sapiens 
2015-08-24 | E-GEOD-65473 | biostudies-arrayexpress
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