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ProteomicsK63-Linked Ubiquitylation of S2P-RNAPII Regulates Transcription in a DNA-PK Inter-Dependent Manner in Response to Double-Strand Breaks
The goal of this experiment was to conduct immunoprecipitation (IP) on lysates from control and neocarzinostatin (NCS)-treated U2OS cells (at 30 minutes and 2 hours) to identify the proteins that interact with Polr2a and to investigate how NCS treatment influences the relative abundance of Polr2a an...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD059497 | Pride
U2os cells Mass spectrometry Immunoprecipitation Ip Lfq Label-free quantitation 
ProteomicsPathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury
Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM antibodies recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14862 | biostudies-arrayexpress
TranscriptomicsNotch signaling-dependent gene expression in the developing mouse lung
Transcriptional profiling of Control and RbpjkCNULL lungs from E18.5. For microarray profiling, total RNA from E18.5 lungs was submitted for labeling and hybridization (Mouse Gene 1.0 ST Whole Genome Array, Affymetrix) to the Boston University Microarray Core facility. Clara cells (CCs) are a morph...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-52926 | biostudies-arrayexpress
TranscriptomicsBurkholderia pseudomallei transcriptional adaptation in macrophage
This study reports the expression profile of intracellular B. pseudomallei following infection of human macrophage-like U937 cells. The transcriptome of intracellular B. pseudomallei harvested from macrophage cells over an infection period of 6 hr (1, 2, 4 and 6 hr post-infection) were compared to i...
ORGANISM(S): Burkholderia pseudomallei 
2011-12-31 | E-GEOD-27558 | biostudies-arrayexpress
UnknownNeuronal activity drives pathway-specific depolarization of peripheral astrocyte processes.
Not available
S-EPMC9988390 | biostudies-literature
TranscriptomicsAged animals generate a robust immune response against swine origin 2009 pandemic H1N1 influenza A virus
In June 2009, the World Health Organization declared the first influenza pandemic of the 21st century, due to the emergence and rapid spread of new swine origin H1N1 influenza A virus. In contrast to seasonal influenza infections, which typically cause morbidity and mortality in the elderly, this vi...
ORGANISM(S): Macaca mulatta 
2012-06-05 | E-GEOD-38502 | biostudies-arrayexpress
TranscriptomicsLinkage of genomic biomarkers to whole organism endpoints in a Toxicity Identification Evaluation (TIE)
Aquatic organisms are exposed to many toxic chemicals and interpreting the cause and effect relationships between occurrence and impairment is difficult. Toxicity Identification Evaluation (TIE) provides a systematic approach for identifying responsible toxicants. TIE relies on relatively uninforma...
ORGANISM(S): Ampelisca abdita 
2012-12-21 | E-GEOD-41463 | biostudies-arrayexpress
TranscriptomicsHost transcriptional reprogramming across diverse strains of the rice bacterial leaf streak pathogen Xanthomonas oryzae pv.oryzicola
We performed RNA-Seq of leaves of Oryza sativa L. ssp. japonica cv. Nipponbare 48 hours after inoculation with 10 geographically diverse strains of Xanthomonas oryzae pv. oryzicola, the causal agent of bacterial leaf streak. Results provide insight into the molecular basis of bacterial leaf streak, ...
ORGANISM(S): Oryza sativa Japonica Group 
2015-05-01 | E-GEOD-67588 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the effect of S78454, a pan histone deacetylase inhibitor, on megakaryopoiesis derived from human CD34+ cells
S78454 (Abexinostat, PCI-24781) is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia, whose mechanism is partially understood. We have tested its effect at doses reached in patients plasma o...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MTAB-1180 | biostudies-arrayexpress
TranscriptomicsGenetic analysis of a Zika Virus Envelope Glycosylation and Non-structural protein 4B P36 Double Mutant
Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Live attenuated vaccines have been successfully used to combat infection by flaviviruses, such as yellow fever and Japanese encephalitis viruses. A Zika virus harboring combined mutations in the envelope...
ORGANISM(S): Zika virus 
2021-12-31 | E-MTAB-9496 | biostudies-arrayexpress
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