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TranscriptomicsGenome-wide comparison of trisomy 21 iPSCs and derived isogenic disomy 21 iPSCs.
Human trisomies can alter cellular phenotypes and produce congenital abnormalities such as Down Syndrome (DS). Here we have generated induced pluripotent stem cells (iPSCs) from DS fibroblasts, and introduced a TKNEO transgene into one copy of chromosome 21 by gene targeting. When selecting agains...
ORGANISM(S): Homo sapiens 
2012-10-23 | E-GEOD-38931 | biostudies-arrayexpress
GenomicsEpigenetic modifications and chromosome conformations of the beta globin locus throughout development
Human embryonic stem cells provide an alternative to using human embryos for studying developmentally regulated gene expression. The co-expression of high levels of embryonic epsilon and fetal gamma globin by the hESC-derived erythroblasts allows the interrogation of epsilon globin regulation at the...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-35375 | biostudies-arrayexpress
TranscriptomicsTranscriptional environment and chromatin modifications interplay decides globin expression patterns.
Background: Developmental stage-specific globin expression is a complex phenomenon that involves both trans- and cis-acting elements. While functional analyses ensuing recent genome-wide association studies have highlighted the important roles of trans-factors in regulating hemoglobin expression, th...
ORGANISM(S): Homo sapiens 
2012-08-19 | E-GEOD-31523 | biostudies-arrayexpress
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