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MetabolomicsAlterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis

PURPOSE: Amino acids (AAs) play important physiological roles in living cells. Some amino acid changes in blood are specific for autoimmune disorders, and some are specific for thyroid cancer. The aims of this study were to profile AA metabolites in the serum of patients with pap...

2023-08-09 | MTBLS8012 | MetaboLights
TranscriptomicsTranscription profiling of micro-RNA genes in human papillary thyroid carcinoma
We show that numerous miRNAs are transcriptionally up-regulated in papillary thyroid carcinoma (PTC) tumors compared with unaffected thyroid tissue. Among the predicted target genes of the three most upregulated miRNAs (miRs 221, 222 and 146b), only less than 15% showed significant downexpression i...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-3467 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human papillary thyroid carcinoma and normal thyroid to assess the role of miRNA genes in papillary thyroid carcinoma
Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC). We show that numerous miRNAs are transcriptionally up-regulated in PTC tumors compared with unaffected thyroid tissue. A set of 5 miRNAs including the 3 most...
ORGANISM(S): Homo sapiens 
2005-02-28 | E-TABM-68 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of human papillary thyroid carcinomas
RNA-Sequencing analysis of 18 papillary thyroid carcinoma biopsies and of 4 healthy donors' thyroids. In this analysis we assessed differential gene expression and investigated the mutational landscape in this tumor type. Analysis of gene fusion was also performed, leading to the identification of a...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-64912 | biostudies-arrayexpress
ProteomicsPrognostic significance of the proteome profile of well differentiated papillary thyroid carcinoma
This research will evaluate the role of tissue proteome profile in regional metastatic disease. Considering that one of the main factors of survival in patients with papillary thyroid carcinoma is the presence of regional or distant metastatic disease, this research will focus on the difference in t...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD042415 | Pride
Proteomics  papillary thyroid carcinoma  metastasis 
ProteomicsProteomics analysis of cystic fluid from human cystic papillary thyroid carcinoma
Here we have performed quantitative and qualitative profiling of the proteome of cystic fluid from human cystic papillary thyroid carcinoma with the aim to identify specific proteins and pathways involved in cystic fluid from human cystic papillary carcinoma, as well as possible diagnostic markers.
ORGANISM(S): Homo sapiens (Human) 
2015-05-20 | PXD000996 | Pride
Cystic fluid Isoelectric focusing Biomarker discovery Proximal fluid Papillary thyroid carcinoma 
ProteomicsMultiomics analysis of Papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCdelta for tumorigenesis
Papillary thyroid carcinoma (PTC) is one of the most common forms of thyroid cancer with a cure rate of over 90% after surgery. However, aggressive forms may still occur, and personalized therapeutic strategies are increasingly required. We subjected patient materials from a cohort of patients whose...
ORGANISM(S): Homo Sapiens (human) 
2023-02-22 | PXD034229 | JPOST Repository
GenomicsTargeted sequencing of papillary thyroid cancer genome of Indian origin
The study involves targeted sequencing of 22 orphan FFPE tumors obtained from papillary thyroid carcinoma patients of Indian origin. With this, we aim to describe the mutation profile of this specific subset of papillary thyroid cancer patients. This knowledge will further allow us to gain an insigh...
ORGANISM(S): Homo sapiens 
2026-10-04 | E-MTAB-14513 | biostudies-arrayexpress
TranscriptomicsSporadic and Post-Chernobyl Papillary Thyroid Cancers
We compared the expression profiles of papillary thyroid tumors from the Chernobyl Tissues Bank (CTB) with tumors from French patients with no history of exposure to radiations. Keywords: papillary thyroid cancer vs. patient-matched healthy adjacent thyroid thyroid papillary cancer vs. patient-match...
ORGANISM(S): Homo sapiens 
2007-07-11 | E-GEOD-3950 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome sequencing of papillary thyroid cancer of Indian origin
The study involves whole transcriptome sequencing of 40 orphan FFPE tumors obtained from papillary thyroid carcinoma patients of Indian origin. With this, we aim to describe the expression profile, fusion genes and pathogen profile of this specific subset of papillary thyroid cancer patients. This ...
ORGANISM(S): Homo sapiens 
2025-11-09 | E-MTAB-12476 | biostudies-arrayexpress
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