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TranscriptomicsTranscription profiling of human megakaryocytic differentiation primary CD34+ cell culture
Little is known about the global transcriptional program underlying megakaryocytic (Mk) differentiation, maturation, and apoptosis. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of Mk differentiation human CD34-positive hematopoietic stem and progenitor cells cultured ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CHRF-288 cell line after phorbol ester stimulation
Little is known about the global transcriptional program underlying megakaryocytic (Mk) differentiation, maturation, and apoptosis. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of phorbol-ester-induced Mk differentiation of the megakaryoblastic CHRF-288-11 (CHRF) cell...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3838 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CHRF-288-11 and primary human megakaryocytic cell cultures provide novel insights into lineage-specific differentiation
This SuperSeries is composed of the following subset Series:

GSE3838: Temporal expression profile of CHRF-288 cell line after phorbol ester stimulation
CHRF-288 cells were cultured in the presence of 10 ng/mL phorbol ester (PMA) or equivalent volume of DMSO solvent (0.02%). Unstimulated ...
ORGANISM(S): Homo sapiens 
2008-01-18 | E-GEOD-8914 | biostudies-arrayexpress
TranscriptomicsTranscription of human thrombopoietin-induced megakaryocyte differentiation with and without nicotinamide vs. Universal reference sample
Culture of hematopoietic stem and progenitor cells in the presence of thrombopoietin induces megakaryocytic differentiation. Addition of nicotinamide to thrombopoietin-stimulated cultures results in significant increases in megkaryocytic differentiation including greater polyploidization and enhanc...
ORGANISM(S): Homo sapiens 
2009-04-08 | E-GEOD-4974 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary T cell culture and T cell response to oxidative stress
Little is known about the global transcriptional program underlying T-cell activation and T-cell response to oxidative stress. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of human T-cell activation and T-cell response to H2O2 stress. The goal of this study was to id...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6607 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary CD8+ T cell activation
Little is known about the global transcriptional program underlying CD8+ T-cell activation. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of human CD8+ T-cell activation. The goal of this study was to identify genes involved in the various facets of human CD8+ T-cell ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7572 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary CD4+ T cell activation, time series
Little is known about the global transcriptional program underlying CD4+ T-cell activation. Using DNA microarrays and Q-RT-PCR, we examined the transcriptional profile of human CD4+ T-cell activation. The goal of this study was to identify genes involved in the various facets of human CD4+ T-cell ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7571 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4114 | biostudies-arrayexpress
TranscriptomicsShear flow vs. static culture of d9 and d12 megakaryocytes
d9 and d12 Mks were either cultured statically or subjected to shear flow for 30 min; at d9, half the Mks were placed back in culture for 30 min (60 min time point) Megakaryocytes (Mks) are exposed to shear flow as they migrate from the bone marrow hematopoietic compartment into circulation thus rel...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-75766 | biostudies-arrayexpress
ModelsSenger2008 - Genome-scale metabolic network of Clostridium acetobutylicum (iCac802)
Senger2008 - Genome-scale metabolic network of Clostridium acetobutylicum (iCac802) This model is described in the article: Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis. Senger RS, Papoutsakis ET. Biotechnol. Bioeng. 20...
2015-07-30 | MODEL1507180027 | BioModels
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