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ProteomicsParadigm of biased PAR1 activation and inhibition in endothelial cells dissected by phosphoproteomics
Objective: Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of protease-activated receptors (PARs). The predominant thrombin receptor is PAR1 and in endothelial cells (ECs) thrombin dynamically regulates a plethora of phosphorylation events...
ORGANISM(S): Homo sapiens (Human) 
2017-08-22 | PXD004264 | Pride
Endothelial cells Par1-inhibitors Silac Par1 Thrombin Phosphoproteomics 
UnknownTesting the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function.
Not available
S-EPMC7364184 | biostudies-literature
ProteomicsQuantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells
Thrombin is the key serine protease of the coagulation cascade and a potent trigger of protease-activated receptor (PAR)1-mediated platelet aggregation. In recent years, PAR1 has become an appealing target for anticoagulant therapies. However, the inhibitors that have been developed so far increase ...
ORGANISM(S): Homo sapiens (Human) 
2014-02-06 | PXD000597 | Pride
Endothelial cells Silac Thrombin Phosphoproteomics Par Secretome 
TranscriptomicsSenescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1
Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor prognosis. Current treatments are insufficient in improving the prognosis of lung cancer patients with comorbid idiopathic pulmonary fibrosis (IPF-LC). Senescent fibroblasts play a pivotal role within the tumor mi...
ORGANISM(S): Homo sapiens 
2024-10-21 | GSE279637 | GEO
UnknownA KLK4 proteinase substrate capture approach to antagonize PAR1.
Not available
S-EPMC8352894 | biostudies-literature
UnknownInteraction of thrombin with PAR1 and PAR4 at the thrombin cleavage site.
Not available
S-EPMC2553362 | biostudies-literature
UnknownMacrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.
Not available
S-EPMC7717035 | biostudies-literature
UnknownTargeting biased signaling by PAR1: function and molecular mechanism of parmodulins.
Not available
S-EPMC10646804 | biostudies-literature
UnknownPAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.
Not available
S-EPMC2879918 | biostudies-literature
UnknownProtease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
Not available
S-EPMC2956715 | biostudies-literature
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