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ProteomicsAtherosclerotic environment effect over CAC pre-angiogenic role
In response to vascular injury, early EPC or Circulating angiogenic cells (CAC) are thought to be recruited to the damaged areas, participating mainly in a paracrine fashion, by releasing pro-angiogenic factors, promoting the mobilization of other cell populations such as the late EPC, or endothelia...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019395 | Pride
Proteomics Angiogenesis Circulating angiogenic cells Atherosclerotic factors Paracrine role Endothelial colony forming cells Secretome 
TranscriptomicsChlamydia trachomatis serogroup D disturbs epithelial tissue homeostasis in Fallopian tubes via paracrine Wnt signalling
Chlamydia trachomatis is the causative agent of sexually transmitted disease with the highest prevalence in the world today. Although, sensitive to antibiotic treatment, Ctr is also a major cause of infertility due to significant cell damage caused to the genital tract of affected women. Occlusion o...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26692 | biostudies-arrayexpress
TranscriptomicsUterine stromal cell_cultured with uNK conditioned Medium
The endometrium contains a distinct population of immune cells consisting of 70% natural killer (NK) cells that undergo cyclic changes during the menstrual cycle. However, how these uterine NK (uNK) cells interact with uterine stromal cells (SC) remains unclear. We therefore investigated the paracri...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-9718 | biostudies-arrayexpress
ProteomicsParacrine interactions between epithelial cells promote colon cancer growth
Tumors are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in affecting tumor growth is well established, the impact of mutant cancer cells on healthy surrounding tissues remains poorly defined. Here, we unco...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-09 | PXD020002 | Pride
Intestine Organoids Silac Conditioned medium Tumoroids 
TranscriptomicsOxygen-dependent osteocyte transcriptomic adaptations occur without modulation of endothelial gene expression via osteocyte paracrine signaling
Bone regeneration remains clinically challenging, partly due to limited knowledge of the cellular mechanisms governing bone repair. Osteocytes, which constitute the majority of bone cells, form an dendritic network and are central regulators of skeletal homeostasis. Residing in a mineralized and low...
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-16618 | biostudies-arrayexpress
ProteomicsProteome analysis of adipose-derived stem cells cultured under clinically relevant conditions in a wound healing perspective
There is a large body of evidence supporting the beneficial role of adipose-derived stem cells (ASCs) in tissue repair and regeneration. These effects appear to be mainly mediated by paracrine signaling pathways and enhanced during hypoxia. Mass spectrometry (MS) represents a valuable tool for prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080858 | MassIVE
TranscriptomicsCoculture with lin-/c-kit+ Stem Cells leads to a Paracrine Mediated Inhibition of Apoptosis in Cardiomyocytes
Background: Experimental studies have suggested that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardioprotective mediators, we performed a systematic analysis of the differential gene expr...
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-21098 | biostudies-arrayexpress
TranscriptomicsInduction of hepatocellular carcinoma through activation of stromal cells in Pdgf-c transgenic mice
Liver cirrhosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes patients to tumorigenesis are not well understood. Transgenic mice expressing platelet-derived growth factor C (Pdgf-c) under the control of the albumin pr...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-38199 | biostudies-arrayexpress
UnknownAtherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo.
Not available
S-EPMC7432497 | biostudies-literature
UnknownParacrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice.
Not available
S-EPMC11696296 | biostudies-literature
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