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TranscriptomicsEpigenomic characterization of patient-derived lung tumoroids using DNA methylation profiling
DNA methylation analysis of patient-derived lung tumoroids and matched healthy organoids demonstrates preservation of tumor-specific epigenomic identity during long-term culture. Tumoroids maintain the methylation landscape of their parental tumors, with samples from the same patient clustering toge...
ORGANISM(S): Homo sapiens 
2025-12-29 | E-MTAB-16020 | biostudies-arrayexpress
TranscriptomicsBRBseq performed on tumoroids and corresponding renal tumor tissues
To evaluate genetic similarities between tumoroids and the corresponding tumor tissues, we performed RNA sequencing of cells for each experimental condition. Since we injected human cancer cells into mice, cancer cells in the tumors were human while microenvironmental cells (i.e. Fibroblasts, Immune...
ORGANISM(S): Homo sapiens 
2023-06-30 | E-MTAB-12928 | biostudies-arrayexpress
TranscriptomicsscRNAseq dataset from neuroblastomas tumoroids
Neuroblastoma (NB), a pediatric cancer arising from disrupted sympathetic neuron differentiation, exhibits marked heterogeneity and limited therapeutic options. To better understand its molecular circuitry dynamics, we applied CARDAMOM, a novel Gene Regulatory Network (GRN) inference framework to s...
ORGANISM(S): Homo sapiens 
2026-07-07 | E-MTAB-16741 | biostudies-arrayexpress
GenomicsscRNAseq dataset from neuroblastomas tumoroids
scRNAseq dataset from neuroblastomas tumoroids
PRJEB109955 | ENA
ProteomicsEstablishment and characterization of a tumoroid biobank derived from dog patients’ mammary tumors for translational research
Breast cancer is the most frequent cancer among women causing the greatest number of cancer-related deaths. Cancer heterogeneity is a main obstacle to therapies. Around 96% of the drugs fail from discovery to the clinical trial phase probably because of the current unreliable preclinical models. New...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2023-03-11 | PXD031440 | Pride
Dog patients Drug screening Breast cancer Tumoroid Biobank 
GenomicsSingle cell RNA sequencing of primary human hepatoblastoma tumoroids
Single cell RNA sequencing of primary human hepatoblastoma tumoroids
PRJNA978586 | ENA
GenomicsTranscriptional profiling of FOLFIRI treated VAKPS Tumoroids
Transcriptional profiling of FOLFIRI treated VAKPS Tumoroids
PRJNA996913 | ENA
GenomicsWhole-genome RNAsequencing of intestinal organoids and tumoroids
Whole-genome RNAsequencing of intestinal organoids and tumoroids
PRJNA641645 | ENA
GenomicsBRBseq performed on tumoroids and corresponding renal tumor tissues
BRBseq performed on tumoroids and corresponding renal tumor tissues
PRJEB62035 | ENA
ProteomicsMechanosensitive interactions of tumoroids with an engineered environment promote cell proliferation and enhance drug response detection
Despite remarkable advances in reproducing ever more sophisticated ex-vivo models, foundational challenges remain in standardizing and scaling up organoid culture. Here, we introduce a novel technology for high-throughput derivation and high-content analysis of tumoroids. This technology relied on m...
ORGANISM(S): Homo sapiens (Human) 
2025-07-24 | PXD058623 | Pride
Mechanotransduction Bladder cancer Ecm  organoid Urothelial cancer 
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