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TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
TranscriptomicsThe dikaryon formation (mating) transcriptome of the basidomycete fungus Coprinopsis cinerea (Coprinus cinereus)
Mating compatibility in C. cinerea is controlled by two loci, A and B. Following fusion of undifferentiated hyphal cells, a complex program is initiated which results in the maintenance of one nucleus from each parent in every cell (the dikaryon). We identified downstream targets of the A locus (A...
ORGANISM(S): Coprinopsis cinerea 
2010-06-21 | E-GEOD-20628 | biostudies-arrayexpress
TranscriptomicsHematopoietic differentiation of human embryonic stem cells - timecourse and d7 CD34 and CD41 fractions
This study aimed to examine gene expression in human ES cells (the RUNX1C GFP reporter line) differentiated towrads hameatopoietic mesoderm in a defined serum free medium. At day 7 of differentiation, the cells were sorted into fractions based on CD34 and CD41 expression and the four fractions analy...
ORGANISM(S): Homo sapiens 
2015-01-13 | E-GEOD-64876 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomic analysis of human milk from healthy mothers reveals drivers of metabolite variability.
Understanding the human milk metabolome can help inform infant nutrition and health. Untargeted metabolomics was used to study breast milk from 31 healthy participants to assess the shared metabolites in milk from participants with various backgrounds and understand how different demographic, health...
2024-10-04 | MTBLS2419 | MetaboLights
TranscriptomicsTranscription profiling of human breast cancer cell lines to investigate p53 status in breast cancer
Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation statu...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3178 | biostudies-arrayexpress
MetabolomicsMetabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor (Untargeted urine UPLC-MS assay)
BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at non relevant doses or in combination with other r...
2019-05-28 | MTBLS596 | MetaboLights
ProteomicsMouse sciatic nerve LC-MSMS - Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration
The peripheral nervous system (PNS) regenerates after injury. However regeneration is often compromised in case of large lesions, the speed of axon reconnection to their target being critical for successful functional recovery. After injury, mature Schwann cells (SCs) convert into repair cells that ...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-17 | PXD005383 | Pride
Mouse sciatic nerve lc-msms 
UnknownEarly life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study.
Not available
S-EPMC9090335 | biostudies-literature
TranscriptomicsEffect of Advanced Paternal Age on Copy Number Variation in Offspring (custom array)
The offspring of older fathers have an increased risk of neurodevelopmental disorders such as schizophrenia and autism. It has been proposed that de novo point mutations and copy number variants (CNVs) in the continually dividing spermatogonia underlie this association. In light of the evidence impl...
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-29454 | biostudies-arrayexpress
TranscriptomicsEffect of Advanced Paternal Age on Copy Number Variation in Offspring(commercial array)
The offspring of older fathers have an increased risk of neurodevelopmental disorders such as schizophrenia and autism. It has been proposed that de novo point mutations and copy number variants (CNVs) in the continually dividing spermatogonia underlie this association. In light of the evidence impl...
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-29455 | biostudies-arrayexpress
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