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TranscriptomicsComparing bacterial community composition of healthy and dark-spot-affected Siderastrea siderea in Florida and the Caribbean.
Coral disease is one of the major causes of reef degradation and therefore of concern to management and conservation efforts. Dark Spot Syndrome (DSS) was described in the early 1990’s as brown or purple amorphous areas of tissue on a coral and has since become one of the most prevalent diseases rep...
ORGANISM(S): mixed sample 
2014-09-30 | E-GEOD-60622 | biostudies-arrayexpress
UnknownAchieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles.
Not available
S-EPMC9024546 | biostudies-literature
ProteomicsDesign and development of IKZF2 and CK1α dual degraders
Lenalidomide achieves its therapeutic efficacy by recruiting and removing proteins of therapeutic interest through the E3 ligase substrate adapter cereblon. Here, we report the rational design and characterization of 81 cereblon ligands for their ability to degrade the transcription factor Helios (I...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD045327 | Pride
Protein degradation Molecular glue 
MetabolomicsA Python-based pipeline for preprocessing LC-MS data for untargeted metabolomics workflows
Preprocessing data in a reproducible and robust way is one of the current challenges in untargeted metabolomics workflows. Data curation in liquid chromatography-mass spectrometry (LC-MS) involves the removal of unwanted features (retention time; m/z pairs) to retain only high-quality data for subse...
2020-11-21 | MTBLS1919 | MetaboLights
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
TranscriptomicsRegulatory networks define phenotypic classes of human stem cell lines
Stem cells are defined as self-renewing cell populations that can differentiate into multiple distinct cell types. However, hundreds of different human cell lines from embryonic, fetal, and adult sources have been called stem cells, even though they range from pluripotent cells, typified by embryon...
ORGANISM(S): Homo sapiens 
2008-08-25 | E-GEOD-11508 | biostudies-arrayexpress
ProteomicsBiophysical and proteomic analyses suggest functions of Pseudomonas syringae pv tomato DC3000 extracellular vesicles in bacterial growth during plant infection
Vesiculation is a process employed by Gram-negative bacteria to release extracellular vesicles (EVs) into the environment. Bacterial EVs contain molecular cargo from the donor bacterium and play important roles in bacterial survival and growth. Here, we describe EV production in plant-pathogenic Pse...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2023-10-24 | PXD023971 | Pride
Pattern-triggered immunity Proteomics Arabidopsis thaliana Nta Pto dc3000 Extracellular vesicles Pti Nanoparticle tracking analysis Evs 
TranscriptomicsGene expression analysis of four conditions for Puccinia graminis f. sp. tritici
Puccinia graminis f. sp. tritici is the cause of wheat stem rust. A microarray was designed from genes predicted from the P. graminis f. sp. tritici genome assembly, and gene expression measured for four conditions which include wheat or barley infecting growth stages initiated by urediniospores. m...
ORGANISM(S): Puccinia graminis f. sp. tritici 
2010-12-31 | E-GEOD-25020 | biostudies-arrayexpress
UnknownManagement of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Not available
S-EPMC6481621 | biostudies-literature
UnknownCombination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer.
Not available
S-EPMC9812941 | biostudies-literature
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