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ProteomicsPARP1-SNAI2 Transcription Axis Drives Resistance to PARP Inhibitor, Talazoparib
The synthetic lethal association between BRCA deficiency and poly (ADP-ribose) polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA-mutated tumors. PARPis also demonstrate activity in non-BRCA mutated tumors presumably through induction of PARP1-DNA trapping. Despit...
ORGANISM(S): Homo sapiens (Human) 
2022-07-08 | PXD033530 | Pride
Parp1 Drug resistance Talazoparib 
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