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TranscriptomicsscRNA-seq of hPSC-derived human intestinal organoids with endogenous vascular endothelial cells
The development of human pluripotent stem cell (hPSC)- derived small intestinal organoids (HIOs) has led to an improved understanding of human intestinal development and physiology. HIOs generated using directed differentiation lack some cellular populations found in the native organ, including vasc...
ORGANISM(S): Homo sapiens 
2020-12-20 | E-MTAB-9228 | biostudies-arrayexpress
GenomicsMethylation orofiling of human stem cell reprogramming by targeted bisulfite sequencing
We report a method for specific capture of an arbitrary subset of genomic targets for single molecule bisulfite sequencing, and for digital quantitation of DNA methylation at a single nucleotide resolution. We used targeted bisulfite sequencing to characterize the changes of DNA methylation during t...
ORGANISM(S): Homo sapiens 
2009-08-28 | E-GEOD-15007 | biostudies-arrayexpress
MetabolomicsA shotgun metabolomics approach to characterize the dissolved organic matter pool in the Samail Ophiolite aquifer
The process of serpentinization has been implicated in supporting life on both early Earth and other worlds in our Solar System. While numerous studies have provided clues to the survival strategies of microbial communities in serpentinizing environments on modern Earth, characterizing microbial act...
2023-03-02 | MTBLS6081 | MetaboLights
TranscriptomicsRNA-Seq of human hematopoietic stem and progenitor cells to study membrane repair following electroporation (EP) or filtroporation (FP) disruption based strategies for intracellular delivery
This experiment investigates how different intracellular delivery methods, specifically filtroporation (FP) and electroporation (EP) affect gene editing efficiency and cellular responses in human hematopoietic stem and progenitor cells. By comparing these methods, results show how mechanical versus ...
ORGANISM(S): Homo sapiens 
2025-10-30 | E-MTAB-15741 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.
Epidemiological studies provide strong evidence that consumption of cruciferous vegetables, such as broccoli, can significantly reduce the risk of developing cancers. Sulforaphane (SFN), a phytochemical derived from cruciferous vegetables, induces anti-proliferative and pro-apoptotic responses in pr...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-48812 | biostudies-arrayexpress
ProteomicsInflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomic insight
Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a relatively recently described dental disorder, commonly found in horses above the age of 15 years old (Carsten Staszyk et al. 2008). The disease was first categorised as EOTRH in 2008, following the identification of clinical cas...
ORGANISM(S): Equus caballus (Horse) 
2025-06-16 | PXD051310 | Pride
Dental Teeth Equine Proteomics 
UnknownDENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior
Not available
S-JCBD-201407068 | bioimages
UnknownCrowd-sourced machine learning prediction of long COVID using data from the National COVID Cohort Collaborative.
Not available
S-EPMC11462169 | biostudies-literature
ProteomicsStructure of an essential inner membrane protein-LPS complex identifies a novel anti-microbial peptide
Lipopolysaccharide (LPS) resides in the outer membrane (OM) of Gram-negative bacteria where it is responsible for barrier function and immune modulation. LPS is the target of polymyxins, last-resort antibiotics whose clinical use is threatened by increasing resistance. Steps in LPS biogenesis are ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2019-05-08 | MSV000083754 | MassIVE
UnknownInherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Not available
S-EPMC4302212 | biostudies-literature
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