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TranscriptomicsTranscriptional regulation in pluripotent stem cells by Methyl CpG binding protein 2 (MeCP2)
Rett syndrome (RTT) is one of the most prevalent female mental disorders. De novo mutations in methyl CpG binding protein 2 (MeCP2) are a major cause of RTT. MeCP2 regulates gene expression as a transcription regulator as well as through long-range chromatin interaction. Because MeCP2 is present on ...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51607 | biostudies-arrayexpress
TranscriptomicsTranscriptome Signature and Regulation in Human Somatic Cell Reprogramming
Reprogramming of somatic cells produces induced pluripotent stem cells (iPSCs) that are invaluable resources for biomedical research. Transcriptional and epigenetic changes have been investigated to facilitate our understanding of the reprogramming process. Here, we extended the previous transcripto...
ORGANISM(S): Homo sapiens 
2015-04-16 | E-GEOD-67915 | biostudies-arrayexpress
TranscriptomicsExpression data from human iPS cells and fibroblasts
DNA methylation is often inversely correlated with gene expression. We used expression microarrays to determine the relationship between DNA methylation and gene expression in 6 iPS cell lines and the fibroblasts from which they were derived. We isolated RNA from iPS cells and fibroblasts for which ...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18226 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from human iPS cells and fibroblasts
DNA methylation is often inversely correlated with gene expression. We used custom Nimblegen microarrays to determine the relationship between DNA methylation and gene expression in 6 iPS cell lines and the fibroblasts from which they were derived. We isolated genomic DNA from iPS cells and fibrobla...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18227 | biostudies-arrayexpress
TranscriptomicsHuman iPS cells and fibroblasts
This SuperSeries is composed of the following subset Series: GSE18226: Expression data from human iPS cells and fibroblasts GSE18227: DNA methylation data from human iPS cells and fibroblasts Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18111 | biostudies-arrayexpress
TranscriptomicsRegulatory networks define phenotypic classes of human stem cell lines
Stem cells are defined as self-renewing cell populations that can differentiate into multiple distinct cell types. However, hundreds of different human cell lines from embryonic, fetal, and adult sources have been called stem cells, even though they range from pluripotent cells, typified by embryon...
ORGANISM(S): Homo sapiens 
2008-08-25 | E-GEOD-11508 | biostudies-arrayexpress
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