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TranscriptomicsJNK1 Ablation in Mice Confers Long-term Metabolic Protection from Diet-Induced Obesity at the Cost of Increased Skin Oxidative Damage
Obesity and insulin resistance are associated with oxidative stress, which may be implicated in their progression. The kinase JNK1 emerged as a promising drug target for the treatment of obesity and type-2 diabetes. However, JNK1 is a key mediator of the oxidative stress response, promoting either c...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73759 | biostudies-arrayexpress
UnknownCholesterol inhibits M-type K+ channels via protein kinase C-dependent phosphorylation in sympathetic neurons.
Not available
S-EPMC2856299 | biostudies-literature
TranscriptomicsThe coregulator, repressor of Estrogen Receptor Activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization.
Our findings establish a key role for the coregulator, Repressor of Estrogen receptor Activity (REA), in controlling the timing and magnitude of decidualization in human endometrial stromal cells in vitro and in the mouse uterus in vivo, and suggest that REA functions to synchronize uterine differen...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-42376 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling Following DNA Vaccination of Rainbow Trout against Infectious Hematopoietic Necrosis Virus
The Infectious Hematopoietic Necrosic Virus (IHNV) DNA vaccine is based on the viral glycoprotein gene (G gene) and induces a non-specific anti-viral immune response and long-term specific immunity against IHNV in salmonid fishes. This study characterized gene expression responses associated with th...
ORGANISM(S): Oncorhynchus mykiss 
2005-12-09 | E-GEOD-3522 | biostudies-arrayexpress
UnknownMolecular identification of Hymenopteran insects collected by using Malaise traps from Hazarganji Chiltan National Park Quetta, Pakistan.
Not available
S-EPMC11006193 | biostudies-literature
TranscriptomicsMolecular characterization of tumor cells from the cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal disease
We purified tumor cells in the CSF (M-bM-^@M-^\CSFTCM-bM-^@M-^]) from 15 metastatic breast cancer patients diagnosed with leptomeningeal disease using a two-step method involving immunomagnetic enrichment and fluorescence-activated cell sorting (IE/FACS). Magnetic beads coated with mAb to the epithe...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-46068 | biostudies-arrayexpress
UnknownK2p 3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.
Not available
S-EPMC6446730 | biostudies-literature
UnknownEscherichia coli K-12: a cooperatively developed annotation snapshot--2005.
Not available
S-EPMC1325200 | biostudies-literature
UnknownJNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.
Not available
S-EPMC6191003 | biostudies-literature
UnknownAmplifying Colossal Thermal Expansion of a Martensitic Molecular Crystal through Interlayer Shear-Induced Side-Chain Liberation.
Not available
S-EPMC11753603 | biostudies-literature
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