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MetabolomicsSex differences modulate the serum metabolome profiles in Parkinson’s disease patients harbouring pathogenic mutations in GBA1, LRRK2, TMEM175, PARK2, PINK1, and PARK7 genes

Background: Sex and genetic background have an impact on Parkinson’s disease (PD) insurgence, but the comprehension of how these factors affect the circulating profile of PD patients is still an aim of study.

Objectives: In this study we aimed to investigate whether genetic background and ...

2026-06-26 | MTBLS12753 | MetaboLights
MetabolomicsA Python-based pipeline for preprocessing LC-MS data for untargeted metabolomics workflows
Preprocessing data in a reproducible and robust way is one of the current challenges in untargeted metabolomics workflows. Data curation in liquid chromatography-mass spectrometry (LC-MS) involves the removal of unwanted features (retention time; m/z pairs) to retain only high-quality data for subse...
2020-11-21 | MTBLS1919 | MetaboLights
MetabolomicsMultiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers (UPLC-MS assay)

A multiplatform comparison of serum of smokers (n=56) and non-smokers (n=57) using NMR spectroscopy and UPLC-MS was carried out to determine perturbed biochemical functions associated with tobacco smoking. This should be helpful for establishing causal relationships between exposure and adverse e...

2017-01-09 | MTBLS364 | MetaboLights
MetabolomicsAn Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits (GC-MS assay)
Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 6...
2016-11-18 | MTBLS350 | MetaboLights
ProteomicsThe 15-min Subcellular Proteome
This project integrated data-independent acquisition (DIA) with capillary electrophoresis electrospray ionization mass spectrometry (CE-ESI-MS) to enable fast single-cell proteomics. With <15 min of effective separation time in a bottom-up proteomics setting, this technology returned ~1,200 proteins...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2024-09-27 | PXD046467 | Pride
Blastomere Proteomics Stem cell Xenopus laevis Mass spectrometry Data independent acquisition Single cell Capillary electrophoresis 
MetabolomicsThe response of Chlamydomonas reinhardtii to nitrogen deprivation: a systems biology analysis

Drastic alteration in macronutrients causes large changes in gene expression in the photosynthetic unicellular alga Chlamydomonas reinhardtii. Preliminary data suggested that cells follow a biphasic response to this change hinging on the initiation of lipid accumulation, and we hypothesized that ...

2015-06-29 | MTBLS208 | MetaboLights
TranscriptomicsTranscription profiling of mouse anterior interpostus nucleus (AIN) in delayed type eyeblink conditioned mice after training to investigate memory formation of eyeblink conditioning
Anterior interpositus nucleus (AIN) is a proposed site of memory formation of eyeblink conditioning. A large part of the underlying molecular events, however, remains unknown. To elucidate molecular mechanisms, we examined transcriptional changes in the AIN of mice trained with delayed-type eyeblink...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3652 | biostudies-arrayexpress
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
TranscriptomicsTranscription profiling of mouse Anterior interpositus nucleus centred DCN from mice with of delayed-type eyeblink conditioned mice: 3-d paired training and sham negative control groups
Anterior interpositus nucleus (AIN) is a proposed site of memory formation of eyeblink conditioning. A large part of the underlying molecular events, however, remains unknown. To elucidate molecular mechanisms, we examined transcriptional changes in the AIN of mice trained with delayed-type eyeblink...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3651 | biostudies-arrayexpress
ProteomicsAnalysis of protein profile changes in heat stressed Arabidopsis depending on the ATG8 isoform using LC-MS/MS
Arabidopsis possesses nine ATG8 isoforms, and the dominant isoform influences the overall substrate specificity and characteristics of autophagosomes. Plants frequently experience heat stress and subsequently recover to their original temperature. During these processes, autophagosomes undergo conti...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-30 | PXD058038 | Pride
Autophagy Arabidopsis Heat stress N-degron pathway Lc-ms/ms 
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