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ProteomicsA multi-scale map of protein assemblies in the DNA damage response
The DNA damage response (DDR) ensures error-free genome replication and transcription and is disrupted in numerous pathologies including cancer, inflammation and aging1–5. An ongoing challenge is to determine the proteins orchestrating DDR and their organization into protein assemblies and complexes...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD037494 | Pride
Dna repair Dna damage response Protein assembly 
ProteomicsA multi-scale map of protein assemblies in the DNA damage response
The DNA damage response (DDR) ensures error-free genome replication and transcription and is disrupted in numerous pathologies including cancer, inflammation and aging1–5. An ongoing challenge is to determine the proteins orchestrating DDR and their organization into protein assemblies and complexes...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD028064 | Pride
Human Protein assembly map Dna damage response 
ProteomicsThe protein interaction landscape of breast cancer
Cancers have been associated with a diverse array of genomic alterations. To understand such alterations in breast invasive carcinoma at the level of cellular mechanisms, we have applied affinity-purification mass spectrometry to delineate comprehensive biophysical interaction networks for 40 freque...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD025931 | Pride
Breast cancer Ph Human Ub 
ProteomicsThe protein interaction landscape of breast cancer
Cancers have been associated with diverse sets of genomic alterations, many of which are rare with uncertain significance. To understand the cellular mechanisms impacted by such alterations in breast invasive carcinoma, we have applied affinity-purification mass spectrometry to delineate comprehensi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD019639 | Pride
Brca1 Spinophilin Proteomics Protein-protein interaction network Akt Breast cancer 
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