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MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
MetabolomicsMetabolic study of BRCA1 knockout cells and WT cells in homo sapiens

BRCA1 mutations are a hallmark of hereditary ovarian cancer, strongly linked to deficiencies in homologous recombination (HR) DNA repair and impaired DNA replication fork protection. However, its roles in cancer progression beyond maintaining genomic integrity remain poorly understood. Through me...

2026-05-15 | MTBLS12245 | MetaboLights
TranscriptomicsBRCA1 depletion effect on HeLa cells
Analysis of HeLa cells following depletion of BRCA1 tumor supressor using RNAi against BRCA1. Results provide insight into the molecular mechanisms underlying loss of the BRCA1 function. Six samples (three control samples and three BRCA1 depleted samples) have been analysed. For the control, the sam...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22259 | biostudies-arrayexpress
TranscriptomicsNormal human mammary tissues from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women
Gene expression profiles of normal human mammary tissue from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women. RNA was prepared from normal breast tissue (confirmed by pathology) from reduction mammoplasties (n=5) and prophylactic mastectomies of known BRCA1 (n=7) and non-BRC...
ORGANISM(S): Homo sapiens 
2009-08-01 | E-GEOD-17072 | biostudies-arrayexpress
TranscriptomicsBrain BRCA1 conditional knockout
BRCA1 nestin CRE conditional knockout cortrices of P7 animals were compared to wildtype littermates to characterize the mutant phenotype. Keywords: expression BRCA1 conditional knockouts using nestin CRE and a null allele with an inverted neo cassette at the 5' end of the exon 11 of BRCA1 on one fl...
ORGANISM(S): Mus musculus 
2011-09-07 | E-GEOD-6310 | biostudies-arrayexpress
TranscriptomicsExpression data from mammary epithelial cells from BRCA1 mutation carriers and non BRCA1 mutation carriers
Female BRCA1 mutation carriers have a nearly 80% probability of developing breast cancer during their life-time. We hypothesized that the breast epithelium at risk in BRCA1 mutation carriers harbors mammary epithelial cells (MECs) with altered proliferation and differentiation properties. Microarray...
ORGANISM(S): Homo sapiens 
2008-11-19 | E-GEOD-13671 | biostudies-arrayexpress
TranscriptomicsTime-resolved single-cell analysis of Brca1 associated mammary tumorigenesis reveals aberrant differentiation of luminal progenitors
One of the major hurdles for the early detection of cancer is our poor understanding of tumour initiating events. Historically, cancer research has focused on histological and molecular characterisation of established tumours, which has led to the identification of hundreds of putative driver mutati...
ORGANISM(S): Homo sapiens 
2021-02-02 | E-MTAB-10046 | biostudies-arrayexpress
ProteomicsBRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation
BRCA1/BARD1 is a tumor suppressor E3 ubiquitin (Ub) ligase with roles in DNA damage repair and in transcriptional regulation. BRCA1/BARD1 RING domains interact with nucleosomes to facilitate mono-ubiquitylation of distinct residues on the C-terminal tail of histone H2A. These enzymatic domains const...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD035345 | Pride
Kojak Brca1 Cancer Nucleosome Cross-linking mass spectrometry Proxl H2a Xl-ms Bard1 Tumor Ubiquitin ligase 
TranscriptomicsBCLAF1 Chip-chip control (siGFP) and BRCA1 depleted (siBRCA1) 293T cells in the absense or presense of Etoposide
BCLAF1 is a serine-arginine (SR) protein implicated in transcriptional regulation and mRNA splicing. We have recently identified BCLAF1 as part of a novel mRNA splicing complex that is recruited to different genetic promoters by the breast cancer susceptiblity protein, BRCA1 in response to DNA dama...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-47016 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast transformed with five deleterious BRCA1 variants
In order to investigate the molecular mechanisms activated by deleterious BRCA1 variants in yeast, the RNA obtained from yeast cells transformed with five variants exhibiting a phenotypic effect, either on proliferation and/or on HR was hybridized on microarrays in comparison with the RNA from cells...
ORGANISM(S): Saccharomyces cerevisiae 
2009-03-31 | E-MEXP-1867 | biostudies-arrayexpress
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