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ProteomicsBRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation
BRCA1/BARD1 is a tumor suppressor E3 ubiquitin (Ub) ligase with roles in DNA damage repair and in transcriptional regulation. BRCA1/BARD1 RING domains interact with nucleosomes to facilitate mono-ubiquitylation of distinct residues on the C-terminal tail of histone H2A. These enzymatic domains const...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD035345 | Pride
Kojak Brca1 Cancer Nucleosome Cross-linking mass spectrometry Proxl H2a Xl-ms Bard1 Tumor Ubiquitin ligase 
GenomicsOvercoming resistance to anti-VEGF therapy via epigenetic regulation of BARD1 [OVCAR8ip1 BARD1 overexpression]
Overcoming resistance to anti-VEGF therapy via epigenetic regulation of BARD1 [OVCAR8ip1 BARD1 overexpression]
PRJNA1039887 | ENA
GenomicsOvercoming resistance to anti-VEGF therapy via epigenetic regulation of BARD1 [SKOV3 BARD1 siRNA-RNASeq]
Overcoming resistance to anti-VEGF therapy via epigenetic regulation of BARD1 [SKOV3 BARD1 siRNA-RNASeq]
PRJNA1039889 | ENA
TranscriptomicsmiRNA expression profiling of NB4 control cells versus NB4 cells treated with SAHA (Vorinostat)
For a long time, the BARD1 (BRCA1-associated RING domain 1) protein has been considered as a BRCA1 (BReast Cancer susceptibility gene 1, early onset) interactor, and tumor suppressor mutated in breast and ovarian cancers. Despite its functions in a stable heterodimer with BRCA1, there is increasing ...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-37374 | biostudies-arrayexpress
GenomicsBRCA1/BARD1 complex associated RNA in HEK293T cells
BRCA1/BARD1 complex associated RNA in HEK293T cells
PRJNA854896 | ENA
ProteomicsBRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway, and, together with BARD1, forms a heterodimer with ubiquitin E3 activity. The relevance of the BRCA1/BARD1 ubiquitin E3 ac...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD050319 | Pride
Ssdna gaps Ubiquitination Brca1 Bard1 Pcna 
ProteomicsBRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway, and, together with BARD1, forms a heterodimer with ubiquitin E3 activity. The relevance of the BRCA1/BARD1 ubiquitin E3 ac...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD039167 | Pride
Breast cancer Brca1 Pcna Ubiquitin E3 Dna replication 
TranscriptomicsOvercoming resistance to anti-VEGF therapy via epigenetic regulation of BARD1 [OVCAR8ip1 BARD1 overexpression]
Despite widespread use of anti-vascular endothelial growth factor (VEGF) antibody (AVA) for cancer therapy, most patients develop progressive disease after initial response. Therefore, novel strategies are needed to understand and overcome AVA resistance. Here, we identify an unexpected role of BRCA...
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE247653 | GEO
TranscriptomicsOvercoming resistance to anti-VEGF therapy via epigenetic regulation of BARD1 [SKOV3 BARD1 siRNA-RNASeq]
Despite widespread use of anti-vascular endothelial growth factor (VEGF) antibody (AVA) for cancer therapy, most patients develop progressive disease after initial response. Therefore, novel strategies are needed to understand and overcome AVA resistance. Here, we identify an unexpected role of BRCA...
ORGANISM(S): Homo sapiens 
2025-06-17 | GSE247654 | GEO
GenomicsBARD1 is an exploitable therapeutic target for homologous repair proficient pancreatic ductal adenocarcinomas [MiaPaCa-2]
BARD1 is an exploitable therapeutic target for homologous repair proficient pancreatic ductal adenocarcinomas [MiaPaCa-2]
PRJNA1161637 | ENA
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