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TranscriptomicsCrkII transgene induces atypical mammary gland development and tumorigenesis
The v-Crk protein was originally isolated as the oncogene fusion product of the CT10 chicken retrovirus. Cellular homologues of v-Crk include Crk, which encodes two alternatively spliced proteins (CrkI and CrkII), and CrkL. Though CrkI/II proteins are elevated in several types of cancer, including b...
ORGANISM(S): Homo sapiens 
2011-07-17 | E-GEOD-30731 | biostudies-arrayexpress
ProteomicsKnight_KIBRA_2017
This dataset consists of 10 raw MS files and associated peak lists and result files, all acquired on an LTQ Orbitrap Velos or Elite mass spectrometer. Samples were generated by Amber Couzens (Gingras lab) to support the manuscript by Jennifer Knight (Morag Park's lab, McGill U), revealing the role ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-26 | MSV000081111 | MassIVE
TranscriptomicsInhibition of Met results in concomitant inhibition of Akt and STAT3 signaling pathways, while abrogation of negative feedback permits Erk reactivation
Amplification and activation of the Met receptor tyrosine kinase occurs up to 23% of gastric cancers, suggesting that Met is a therapeutic target in these cancers. However, the steady-state signaling events that occur during chronic Met activation, and mechanisms for resistance to Met small-molecul...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-54532 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Wild-type vs. Brpf1-deficient P4 mouse brain
RNA was isolated from three pairs of wild-type and Brpf1-deficient mouse brains (the dorsal cortex part) at postnatal day 4 for microarray analysis. The cDNA samples were then labeled and mixed for hybridization with one array. The data from three arrays were obtained and used for bioinformatic anal...
ORGANISM(S): Mus musculus 
2015-04-08 | E-GEOD-63909 | biostudies-arrayexpress
ProteomicsGingras_Mui_E4orf4_interactions_P107_V5
This submission includes the mass spectrometry data for the manuscript by Mui et al. (E4orf4 interactome). This submission contains 16 files for E4orf4 WT or mutant interactions from HEK293 cells, acquired on LTQ Orbitrap Velos and LTQ Orbitrap Elite. See the README file within "Methods and Protoc...
ORGANISM(S): Human Adenovirus 5 (ncbitaxon:28285) Homo Sapiens (ncbitaxon:9606) 
2015-03-20 | MSV000079082 | MassIVE
UnknownDirected Evolution of Clostridium thermocellum β-Glucosidase A Towards Enhanced Thermostability.
Not available
S-EPMC6801902 | biostudies-literature
TranscriptomicsExtensive re-wiring of epithelial-stromal co-expression networks in breast cancer - ER-positive breast cancer validation dataset
Background: Epithelial-stromal crosstalk plays a critical role in invasive breast cancer (IBC) pathogenesis; however, little is known on a systems level about how epithelial-stromal interactions evolve during carcinogenesis. Results: We develop a framework for building genome-wide epithelial-stroma...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-68744 | biostudies-arrayexpress
TranscriptomicsHeterogeneity of Breast Cancer Vasculature
Tumor-associated breast vasculature was laser-cappture microdissected from IDC breast cancer cases. The goal of the study was to characterize the heterogeneity of breast tumor-associated vasculature and identify gene expression signatures predictive of clinical outcome. common reference design, 32 s...
ORGANISM(S): Homo sapiens 
2010-09-19 | E-GEOD-15363 | biostudies-arrayexpress
TranscriptomicsThe prognostic ease and difficulty of invasive breast carcinoma
Breast carcinoma (BC) have been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or those that seek to identify gene signatures with prognostic or pr...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-58644 | biostudies-arrayexpress
TranscriptomicsMet synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (aCGH data).
Transcriptional profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre. Two-color common reference design. Samples consist of 4 normal tissues, 8 MMTV-Met tumors, 10 MMTV-Met;Trp53fl/+;Cre tumors, and 8 Trp53...
ORGANISM(S): Mus musculus 
2013-03-04 | E-GEOD-41632 | biostudies-arrayexpress
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