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UnknownWeekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma.

Aim

To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC).

Methods

A multi-center, open-label, prospective phase II study was designed. Thirty-three esophageal SCC patients with document...
S-EPMC4394089 | biostudies-literature
ProteomicsAn Anatomically Resolved Comprehensive Mouse Brain Proteome
A mouse brain protein atlas that covers 17 surgically distinctive neuroanatomical regions of the adult mouse brain, each less than 1mm3 in size.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-06-01 | MSV000079789 | MassIVE
UnknownHuman UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling.

Background

Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have been shown to prevent brain damage and improve neurocognition following intraventricular hemorrhage (IVH). However, the molecular mechanisms underlying the effects of hUCB-MSCs are still elusive. Thus, as t...
S-EPMC6249960 | biostudies-literature
ProteomicsParkinson's disease mouse brain proteome profiling
We compared the proteome from a vulnerable region (Substantia nigra pars compacta, SNc) of wild-type and Parkinsonian mice to that of an adjacent, less vulnerable, region (Ventral tegmental area, VTA) and identified several proteins which exhibited both spatiotemporal- and genotype-restricted change...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-12-25 | MSV000080437 | MassIVE
ProteomicsThe anti-metastatic effect of pyruvate dehydrogenase kinase 4 inhibition in bladder cancer via p-AKT, p-ERK, p-Src and p-JNK pathway
To confirm the anti-metastatic effect in bladder cancer cell lines, the PDK4 gene was knocked down and phosphorylated protein changes were compared through LC-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD035005 | Pride
Human Bladder cancer Phosphoproteomics Lc-ms/ms 
UnknownMolecular Characterization and Pathogenesis of H6N6 Low Pathogenic Avian Influenza Viruses Isolated from Mallard Ducks (Anas platyrhynchos) in South Korea.
The subtype H6N6 has been identified worldwide following the increasing frequency of avian influenza viruses (AIVs). These AIVs also have the ability to bind to human-like receptors, thereby increasing the risk of animal-human transmission. In September 2019, an H6N6 avian influenza virus-KNU2019-48...
S-EPMC9143286 | biostudies-literature
ProteomicsLabel-free global proteome profiling of European American and African American bladder tumor patients.
Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared to their European American (EA) counterparts, but the molecular mechanism underlying differences are unknown. . Thus, we performed proteomics analysis of AA and EA BLCA and identified higher mitochondrial OXPHOS spe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-08 | MSV000095559 | MassIVE
UnknownOncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
Rab escort protein-1 (REP1) is linked to choroideremia (CHM), an X-linked degenerative disorder caused by mutations of the gene encoding REP1 (CHM). REP1 mutant zebrafish showed excessive cell death throughout the body, including the eyes, indicating that REP1 is critical for cell survival, a hallma...
S-EPMC5386492 | biostudies-literature
UnknownpH-dependent mechanism of oxygen evolution in highly disordered RuO<sub>2</sub> nanosheets.
Amorphous materials have garnered significant research interest because of their high structural tolerances and useful functionalities. Here, we develop an effective synthesis method for atomically thin, highly disordered RuO2 nanosheets that exhibit a promising electrocatalytic performan...
S-EPMC12820091 | biostudies-literature
ProteomicsUnveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach
A major risk factor for Clostridioides difficile infection (CDI) is the perturbation of the gut microbiota by antibiotic administration, and antibiotic therapy, the standard treatment option for CDI, exacerbates the imbalance of the gut microbiota, leading to a very high recurrent CDI (rCDI) inciden...
ORGANISM(S): Clostridioides difficile ATCC 9689 = DSM 1296 
2024-01-26 | PXD040738 | Pride
Metabolomics Microbe-microbe interaction Clostridioides difficile Molecular mechanism. Bifidobacterium longum Proteomics 
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