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MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
GenomicsH2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics [ChIP-seq]
While it has been clearly established that well positioned H2A.Z-containing nucleosomes flank the nucleosome depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here th...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41371 | biostudies-arrayexpress
UnknownLongitudinal relaxation rate ( R 1 ) in lung: a systematic review and meta-analysis.
Not available
S-EPMC12497672 | biostudies-literature
TranscriptomicsSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
During pneumonic plague, the bacterium Yersinia pestis elicits the development of inflammatory lung lesions that continue to expand throughout infection. This lesion development and persistence is poorly understood. Here, we examine spatially distinct regions of lung lesions using laser capture micr...
ORGANISM(S): Mus musculus 
2015-07-13 | E-GEOD-70819 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver to examine aging induced alterations in hepatic gene expression
Toxicokinetic and metabolism studies are considered crucial to dose setting and interpretation of data from rodent carcinogenicity studies. The metabolism and distribution studies are usually conducted in 6 to 8 week old rodents. However cancer studies generally involve exposures from 6 weeks of a...
ORGANISM(S): Rattus norvegicus 
2008-06-18 | E-GEOD-4270 | biostudies-arrayexpress
TranscriptomicsA Supervised Risk Predictor of Breast Cancer Based on Biological Subtypes
Purpose: The biological subtypes of breast cancer designated as Luminal A, Luminal B, HER2+/ER-, and Basal-like are clinically important for prognosis and planning treatment strategies. Recognizing that there is a continuum in both the spectrum of breast cancer disease and the risk of survival, we s...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10886 | biostudies-arrayexpress
TranscriptomicsSynovial biopsies from RA and PsA patients and skin biopsies from Psoriasis patients under Infliximab treatment
Object: to understand Infliximab treatment effect on the molecular expression of tissue at disease site 4mm punch biopsies were performed on involved and uninvolved skin at baseline in 5 Ps patients. A repeat biopsy was performed at week 2 after IFX therapy at a site adjacent to the baseline biopsy ...
ORGANISM(S): Homo sapiens 
2014-10-29 | E-GEOD-57376 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscle tissue from wild type and RIP140-null mice fed a normal or high-fat diet
Mice which lack transcriptional corepressor RIP140 show muscle fibre-type switching and increased metabolic gene expression. Comparison between skeletal muscle tissue from wild type and RIP140-null mice fed normal or high-fat diet. Switched the diet when mice were 1 month old, then sampled at 3 mon...
ORGANISM(S): Mus musculus 
2022-11-23 | E-BAIR-13 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart from rats exposed to Bis(2-chloroethoxy)methane to investigate heart toxicity and recovery in male fisher rats
Specific gene changes after exposure to the heart toxin, bis(2-chloroethoxy)methane, were analyzed to elucidate critical pathways associated with recovery from heart toxicity. Bis(2-chloroethoxy)methane was administered to male F344/N rats at 0, 200, 400, or 600 mg/kg by dermal exposure for up t...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4254 | biostudies-arrayexpress
TranscriptomicsAgo2 stable cell line
Our genome wide analyses of microRNA expression profiles involve the hybridization of fluorescently labeled RNA samples to custom made, DNA microarrays based on the GAPSII coated slides. We describe the differences in genome wide miRNA expressions between wild type 293 T mammalian cells and Ago2 t...
ORGANISM(S): synthetic construct 
2010-05-19 | E-GEOD-11168 | biostudies-arrayexpress
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