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TranscriptomicsProtein Kinase C Alpha Promotes Tumor Growth by Initiating a Feed-forward Network Involving miR-15a and Cyclin E
Protein Kinase C alpha (PKC) is associated with progression and poor prognosis in head and neck cancer. Previous studies have demonstrated that PKC sustains the proliferative signal by increasing cyclin E expression, leading to enhanced E2F target gene transcription and DNA synthesis. Here we show ...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-10301 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human head and neck squamous cell carcinoma samples reveals a feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle
Patient selection and specimen collection. Thirty-six freshly frozen tumor samples were prospectively collected from patients undergoing surgery or biopsy for HNSCC at the University of North Carolina (UNC) at Chapel Hill (21 patients) and Vanderbilt University (15 patients). All tissues were snap-f...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10300 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human squamous cell carcinoma of the head and neck cells reveals tumor growth and prognosis of squamous cell carcinoma of the head and neck is linked to protein kinase C alpha
Protein Kinase C alpha (PKC) is a critical mediator of cell signaling and cancer growth. We show that PKC inhibitors decrease proliferation in squamous cell carcinoma of the head and neck (SCCHN) cells and abrogate growth of SCCHN tumors in mouse xenografts. Analysis of gene expression arrays reveal...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10299 | biostudies-arrayexpress
TranscriptomicsInsulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; c...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-9600 | biostudies-arrayexpress
UnknownTumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas.
Not available
S-EPMC8029323 | biostudies-literature
TranscriptomicsGene Expression Profiles of Head and Neck Squamous Cell Carcinoma (HNSCC) primary tumors
60 fresh frozen HNSCC from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. 55 tumor samples were collected from the primary tumor and five tumor samples were collected from a local recurrence at the primary ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-686 | biostudies-arrayexpress
UnknownTCF12 is mutated in anaplastic oligodendroglioma.
Not available
S-EPMC4490400 | biostudies-literature
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