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TranscriptomicsThe Paradigm of Macrophage Polarization is not Applicable per seto Human Circulating Monocytes
Macrophage activation is required for the control of innate and adaptive immune responses. The classification in M1 and M2 macrophages based on a combination of small numbers of membrane and soluble markers is operational in murine and human macrophages. If this classification may be extended to cir...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-27658 | biostudies-arrayexpress
TranscriptomicsGranulomatous response to Coxiella burnetii, the agent of Q fever: Activation of type I interferon-related genes
The formation of granulomas is associated with the resolution of Q fever, a zoonosis due to Coxiella burnetii; however the molecular mechanisms of granuloma formation remain poorly understood. We generated human granulomas with peripheral blood mononuclear cells and beads coated with C. burnetii, us...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-37666 | biostudies-arrayexpress
Transcriptomicsgene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients
The goal of the study was to identify difference in gene expression between activated /CD69+ blood cells selected from HTLV-1-infected patient displaying HAM-TSP disease (HTLV-1-associated myelopathy/tropical spastic paraparesis), compared to healthy blood donor /HD (biological sample providers: Dr....
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33859 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary human monocytes (4 healthy donors)
Monocytes were isolated from healthy donors PBMC and sorted for classical and non-classical monocyte subsets. RNA-seq was performed on unstimulated monocytes.
ORGANISM(S): Homo sapiens 
2018-11-09 | E-MTAB-6712 | biostudies-arrayexpress
TranscriptomicsThe multifaceted responses of human monocytes to IFN-gamma and IL-4 are not reducible to M1/M2 polarization of Macrophages
Macrophages are known to be polarized into inflammatory (M1) and immunoregulatory (M2) cells when they are stimulated by agonists such as IFN-gamma and IL-4, respectively. If circulating monocytes may be polarized in response to T cell signals is often misguidedly deduced from macrophage results. He...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-GEOD-36537 | biostudies-arrayexpress
GenomicsChiP-seq of H3K4me3 in primary unstimulated monocytes from 3 healthy donors buffy coats and from 4 CMML patients
Identification of H3K4me3 localization on chromatin in primary unstimulated monocytes
ORGANISM(S): Homo sapiens 
2018-11-09 | E-MTAB-6689 | biostudies-arrayexpress
GenomicsChIP-seq of EGR1 in human primary unstimulated monocytes and in unstimulated human monocytes from three CMML patients
Identification of EGR1 chromatin localization in human primary monocytes (2 donors), in human primary monocytes from 2 CMML patients with TET2 truncating mutations (high VAF) and in human primary monocytes from 1 CMML patients with TET2 truncating mutations with low VAF.
ORGANISM(S): Homo sapiens 
2021-11-15 | E-MTAB-11132 | biostudies-arrayexpress
GenomicsChIP-seq of CSF-1R, H3K4me1, H3K4me3 in human primary unstimulated monocytes and monocytes differentiated 72h with CSF-1 (3 healthy donors buffy coat) and in monocytes from two CMML patients and one healthy donor, EGR1 ChIP-seq in unstimulated monocytes (3 healthy donors buffy coat)
Identification of nuclear CSF-1R, H3K4me1 and H3K4me3 localization on chromatin in human primary monocytes and modification of this localization during monocyte differentiation into macrophage induced by 100ng/mL CSF-1 during 6 hours (1 donor) or 72h (3 donors). Identification of EGR1 chromatin loc...
ORGANISM(S): Homo sapiens 
2019-03-04 | E-MTAB-6305 | biostudies-arrayexpress
TranscriptomicsMinimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA: a proof-of-principle study
This submission contains the data from https://www.biorxiv.org/content/10.1101/795047v2.full This dataset contains processed data of cell-free reduced representation bisulfite sequencing from 60 pediatric cancer samples, in order to classify them according to histopathological diagnosis. Files are ...
ORGANISM(S): Homo sapiens 
2020-02-27 | E-MTAB-8770 | biostudies-arrayexpress
UnknownGenetic studies of body mass index yield new insights for obesity biology.
Not available
S-EPMC4382211 | biostudies-literature
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