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ProteomicsRegulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
PARP15 is a mono-ADP-ribosyltransferase with unknown functions. Its evolutionary relationship with PARP14 suggests roles in antiviral defense; its ability to modify RNA and localization to stress granules point to functions in the regulation of translation. PARP15 also modifies itself and other prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD061403 | Pride
Hdx-ms Parp15 
ProteomicsRegulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
The catalytic domain of PARP15 dimerizes, forming the same dimer interface in solution that had already been captured by X-ray crystallography of the domain. Furthermore, we show that the formation of dimers is a prerequisite for catalytic activity and that monomeric mutant variants of the domain we...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD067296 | Pride
Crosslinking mass spectrometry Parp15 
ProteomicsIdentification of PARP15 enzymatic substrates
Recombinant JNK-interacting protein 3 (JIP3) was incubated with enzymatically active PARP15 and biotinylated NAD to determine residues modified by mono-ADP ribosylation (MAR)
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD051413 | Pride
Poly-adp ribosyltransferase (parp)  parp15 Mono-adp ribosylation  jun kinase (jnk)  jnk-kinase interacting protein 
GenomicsPARP15 promotes vascular barrier integrity in inflammation
PARP15 promotes vascular barrier integrity in inflammation
PRJNA989163 | ENA
TranscriptomicsPARP15 promotes vascular barrier integrity in inflammation
The vascular endothelial barrier, which supports balanced plasma solute and macromolecule composition, controls hemostasis, and limits leukocyte extravasation at homeostasis, is frequently disrupted in inflammation associated with sepsis and other critical illness. Monoclonal gammopathy-associated i...
ORGANISM(S): Homo sapiens 
2024-06-29 | GSE236167 | GEO
UnknownRegulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15.
Not available
S-EPMC12572374 | biostudies-literature
Unknown<i>PARP15</i> Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome).
Not available
S-EPMC11602389 | biostudies-literature
UnknownStructural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Not available
S-EPMC4367243 | biostudies-literature
UnknownA macrodomain-linked immunosorbent assay (MLISA) for mono-ADP-ribosyltransferases.
Not available
S-EPMC5826802 | biostudies-literature
TranscriptomicsDifferential Gene Expression Profiles of Pancreatic Ductal Adenocarcinomas Among African American and Caucasian American Patients
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths. In the United States (US), African Americans (AA) have higher PDAC incidence and mortality than Caucasian Americans (CA). This study aimed to identify distinct gene expression patterns and different...
ORGANISM(S): Homo sapiens 
2025-07-23 | GSE293744 | GEO
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