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ProteomicsNative-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology
One of the earliest pathophysiological perturbations in Alzheimer’s Disease (AD) may arise from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early protein-level (proteomic) alterations in PV-INs can provide key biological and translationally relevant insights. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-04 | PXD043963 | Pride
Alzheimer’s disease Parvalbumin interneurons Proteomics 
GenomicsRibosome-associated RNA sequencing of medial prefrontal cortex parvalbumin interneurons following Foxo1 deletion
Ribosome-associated RNA sequencing of medial prefrontal cortex parvalbumin interneurons following Foxo1 deletion
PRJNA1515282 | ENA
TranscriptomicsDisruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
Since many years, we are interested in the regulation of the intraneuronal chloride concentration. We were the first group reporting a full knockout of the KCl-co-transporter KCC2, which dies immediately after birth due to respiratory failure. Notably, KCC2 loss-of-function mutations are associated ...
ORGANISM(S): Mus musculus 
2022-11-02 | E-MTAB-11147 | biostudies-arrayexpress
GenomicsDOT1L deletion impairs the development of cortical Parvalbumin-expressing interneurons
DOT1L deletion impairs the development of cortical Parvalbumin-expressing interneurons
PRJNA917294 | ENA
GenomicsDisruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
Disruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice
PRJEB48759 | ENA
GenomicsDiscrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons
Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons
PRJNA1021548 | ENA
OtherRibosome-associated RNA sequencing of medial prefrontal cortex parvalbumin interneurons following Foxo1 deletion
FOXO1 is required for maintaining cellular homeostasis in medial prefrontal cortex parvalbumin interneurons. To characterize the molecular consequences of FOXO1 loss, ribosome-associated transcripts were isolated specifically from parvalbumin interneurons in the medial prefrontal cortex of control a...
ORGANISM(S): Mus musculus 
2026-08-26 | GSE344344 | GEO
ProteomicsAutophagy is dispensable for the maintenance of parvalbumin interneurons but required for their inhibitory neurotransmission and memory
Previous studies have demonstrated the requirement of autophagy for neuronal survival and synaptic function, mostly focusing on projection neurons and excitatory neurotransmission. Here, we examine the effects of conditional atg5 ablation in neurons expressing parvalbumin (PV-cKO), which in the fore...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD035264 | Pride
Autophagy Mus musculus Neurons Fusion 
GenomicsA postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons [scRNA-seq]
A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons [scRNA-seq]
PRJNA1079686 | ENA
GenomicsA postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons [CUT&RUN]
A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons [CUT&RUN]
PRJNA1079685 | ENA
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