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GenomicsPancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants
We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1919 | biostudies-arrayexpress
TranscriptomicsA map of open chromatin in human pancreatic islets
High-throughput sequencing of genomic regions isolated using FAIRE (Formaldehyde-assisted isolation of regulatory elements) from three purified pancreatic islet samples For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCO...
ORGANISM(S): Homo sapiens 
2010-01-31 | E-GEOD-17616 | biostudies-arrayexpress
GenomicsImperial College London - Beta Cell Genome Regulation Lab
Data Access Committee EGAC00001000853
EGAC00001000853 | EGA
Genomicsena-DATASET-ICL-01-03-2018-15:32:27:049-427 - samples
Whole Human Islet paired-ended RNA-seq of 64 human pancreatic donors.
EGAD00001003992 | EGA
GenomicsHuman Pancreatic Beta Cell lncRNAs Control Cell-Specific Regulatory Networks
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cel...
EGAS00001002865 | EGA
GenomicsTEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
The genomic regulatory programs that underlie human organogenesis are poorly understood. Human pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer, and diabetes. We have now created maps of transcripts, active enhancers, and transcription factor networks...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-MTAB-3061 | biostudies-arrayexpress
UnknownLRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.
Not available
S-EPMC11659195 | biostudies-literature
UnknownEvaluation of appendicitis risk prediction models in adults with suspected appendicitis.
Not available
S-EPMC6972511 | biostudies-literature
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