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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownMulticenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.
Not available
S-EPMC5993168 | biostudies-literature
GenomicsHigh-throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples By Multiplexed PCR and Next Generation Sequencing
PURPOSE: Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false positive rates. Here, we describe a novel methodology, M...
EGAS00001000674 | EGA
GenomicsMMP-seq tumor samples (FASTQ) - samples
MMP-seq tumor samples (FASTQ)
EGAD00001001108 | EGA
GenomicsMMP-seq cell lines (FASTQ) - samples
MMP-seq cell lines (FASTQ)
EGAD00001001107 | EGA
GenomicsMMP-seq tumor samples, UDG treated (FASTQ) - samples
MMP-seq tumor samples, UDG treated (FASTQ)
EGAD00001001104 | EGA
TranscriptomicsRedefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types,...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-30034 | biostudies-arrayexpress
UnknownEffects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial.
Not available
S-EPMC11157928 | biostudies-literature
Transcriptomicssc-RNA seq of lung leukocytes isolated from ILC2 deficient , IL4 and IL13 conditional knockout and WT control mice at day 9 post N.brasiliensis infection
Many hookworm species migrate through the lung as part of their life cycle and thereby induce tissue damage which primes the development of type 2 immune responses . These responses are crucial for driving the resolution of pathology and for development of adaptive immunity to subsequent infections...
ORGANISM(S): Mus musculus 
2026-09-25 | E-MTAB-16580 | biostudies-arrayexpress
GenomicsNHLBI and NIDDK Sponsored GWAS in Benign Ethnic Neutropenia/Leukopenia (BEN) in African-Americans (age >45 yrs old) from the REGARDS

Benign ethnic neutropenia (BEN) is a clinical condition more commonly observed in African-Americans. It is characterized by a relative reduction in neutrophil count by about 1000 cells per microliter, leading to a decrease in total leukocyte count by similar decrement. Previous reports of this co...

phs000507.v1.p1 | EGA
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