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TranscriptomicsGenetic diversity among Helicobacter pylori strains
Helicobacter pylori colonizes the stomach of half of the world's population, causing a wide spectrum of disease ranging from asymptomatic gastritis to ulcers to gastric cancer. Although the basis for these diverse clinical outcomes is not understood, more severe disease is associated with strains ha...
ORGANISM(S): Helicobacter pylori 
2001-07-25 | E-GEOD-6 | biostudies-arrayexpress
TranscriptomicsInter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity
ZIKV strains belong to three phylogenetic lineages: East African, West African, and Asian/American. RNA virus genomes exist as populations of genetically-related sequences whose heterogeneity may impact viral fitness, evolution, and virulence. The genetic diversity of representative ZIKVs (N=7) fro...
ORGANISM(S): Zika virus 
2019-07-30 | E-MTAB-7771 | biostudies-arrayexpress
ProteomicsProteomic Comparison Between Hyphae and Spores Reveals Pathogenicity Diversity in Mucor Irregularis
Mucor irregularis poses significant clinical risks, including severe disfigurement, with hyphal forms being more commonly encountered in clinical settings compared to spore forms. However, the pathogenic differences between these forms at the protein level remain poorly understood. This study employ...
ORGANISM(S): Mucor irregularis B50 
2025-07-28 | PXD055430 | Pride
Pathogenicity diversity Proteomics， mucor irregularis 
TranscriptomicsJapanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity
The genetic diversity of JEV vaccine strains SA14-14-2, SA14-5-3 and SA14-2-8 and the WT parental WT strain they were derived from, SA14, were sequenced using Illumina technology. Passages of the strains were also sequenced to observe changes in genetic diversity.
ORGANISM(S): Japanese encephalitis virus 
2021-01-21 | E-MTAB-9385 | biostudies-arrayexpress
TranscriptomicsMutation Mapping of 31 Streptococcus suis strains
Identification of Genes and Genomic Islands Correlated with High Pathogenicity through Tilling Microarray-Based Comparative Genomics in S. suis. Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. S. suis isolates have been categorized ...
ORGANISM(S): Streptococcus suis 
2012-08-08 | E-GEOD-26052 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 17 Borrelia burgdorferi isolates of varying pathogenicity and RST gene type to investigate genome plasticity
B. burgdorferi isolates differ in pathogenicity, and a correlation between RST type and pathogenicity was observed: the most invasive of the isolates are associated with RST1 and the least invasive with RST3 (Wang et al. 2001, Wang et al. 2002, Wormser et al. 1999). Comparative genome hybridization ...
ORGANISM(S): Borrelia burgdorferi 
2006-08-15 | E-MEXP-735 | biostudies-arrayexpress
TranscriptomicsComparative Profiling of Pseudomonas aeruginosa Strains Reveals Differential Expression of Novel Unique and Conserved Small RNAs
Pseudomonas aeruginosa is a highly adaptable bacterium which thrives in a broad range of ecological niches and can infect multiple hosts as diverse as plants, nematodes and mammals. In humans, it is an important opportunistic pathogen. This wide adaptability correlates with its broad genetic diversi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-06-04 | E-GEOD-36340 | biostudies-arrayexpress
TranscriptomicsInter and intra-lineage genetic diversity of Zika virus differs for American isolates
Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. ZIKV infections are associated with neurodevelopmental deficiencies termed Congenital Zika Syndrome. ZIKV strains are grouped into three phylogenetic lineages: East African, West African, and Asian, whi...
ORGANISM(S): Zika virus 
2018-12-31 | E-MTAB-5945 | biostudies-arrayexpress
TranscriptomicsStructural and non-structural genes contribute to the genetic diversity of RNA viruses
With the advent of advanced sequencing technology, studies of RNA viruses have shown that genetic diversity contribute to both attenuation and virulence. The differences in genetic diversity of wild-type Asibi virus and 17D-204 vaccine provides an unique opportunity to investigate RNA population th...
ORGANISM(S): Yellow fever virus 
2018-10-16 | E-MTAB-6614 | biostudies-arrayexpress
UnknownGenetic Diversity of Fowlpox Virus and Putative Genes Involved in Its Pathogenicity.
Not available
S-EPMC9603804 | biostudies-literature
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