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MetabolomicsMetabolic flux analysis of glucose through the glycolytic pathway.

C13 whole-labeled glucose was added into the culture medium of tumor cells to analyze the changes of metabolic flux in glycolytic pathway under metformin treatment or without HK2 knockout, and to analyze the glycolytic link affected by HK2 and metformin treatment.

2025-06-26 | MTBLS12643 | MetaboLights
OtherHuwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.
Data from ProteomeXchange, PXD ID: PXD000781. File: KN_Ubi_endo_130528_minus_fr_65min_01.mzml. Published as part of Sci Signal. 2014 Mar 18;7(317):ra26 . From the Abstract: {{i}} In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in ce...
ORGANISM(S): Homo_sapiens_viruses, Human,one_off 
GPM32310000423 | GPMDB
Resource Reanalysis 
TranscriptomicsHuman Wnt signaling pathway (Realtime qPCR array)
Human bone marrow mesenchymal stem cells (BMMSC) and human embryonic mesenchymal stem cells (ESMSC)were used. X-ray irradiation (2Gy) or 0Gy was delivered. After 4 hours, equal amount total RNA from each sample was extracted prior to gene expression analysis. After making cDNA, genes associated with...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-60310 | biostudies-arrayexpress
TranscriptomicsDistinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway
Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on the clinical parameters is inadequate for accurate prognostication. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carrie...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-GEOD-41842 | biostudies-arrayexpress
UnknownFunctional estrogen receptor signaling pathway activity in high-grade serous ovarian carcinoma as compared to estrogen receptor protein expression by immunohistochemistry.
Not available
S-EPMC8338831 | biostudies-literature
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
TranscriptomicsPerturbation of the Notch pathway in Xenopus laevis embryos
The Notch signaling pathway functions in a number of processes during embryologic development, especially the maintenance or aquisition of cell fate. We purturb the Notch signalling pathway in embryonic Xenopus laevis in order to 1) better characterize the downstream targets of Notch signalling, and...
ORGANISM(S): Xenopus laevis 
2014-08-06 | E-GEOD-60127 | biostudies-arrayexpress
TranscriptomicsDNA damage Signaling Pathway PCR Array to profile the expression of human genes regulating in the DNA damage response (DDR) network
Human DNA Damage Signaling Pathway RT2 Profiler Array Kit (Qiagen, Valencia, CA) was used to profile the expression of key genes involved in the DDR network as per the manufacturer’s instructions. U937 cells were incubated with PXD-101 +/- MLN4924 for 16 h, after which the RT2 ProfilerTM DNA damag...
ORGANISM(S): Homo sapiens 
2016-02-05 | E-GEOD-77560 | biostudies-arrayexpress
TranscriptomicsMiRNome and transcriptome aided pathway analysis in human regulatory T cells
Owing to their manifold immune regulatory functions, regulatory T cells (Treg) have received tremendous interests as targets for therapeutic intervention of diverse immunological pathologies or cancer. Directed manipulation of Treg will only be achievable with extensive knowledge about the intrinsic...
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-54953 | biostudies-arrayexpress
TranscriptomicsDevelopment of Pathway Preferential Estrogens Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation in Mice
There is great medical need for estrogens having favorable pharmacological profiles, supporting desirable activities for menopausal women such as metabolic and vascular protection but lacking stimulatory activities on the breast or uterus. Here, we report the development of structurally novel estrog...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-73663 | biostudies-arrayexpress
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