Patient induced pluripotent stem cells

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Classification

bacteria (1)

Study type

Transcription profiling by array (176)
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Lab affiliation

Proteome Dynamics, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin, Germany Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany (2)
Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil (2)
The University of Melbourne (2)
Raymond H. Wittcoff Distinguished Professor and Head Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis, MO 63110 United States of America (1)
Immunopathology of Virus Infections Institute of Virology Technical University of Munich Munich, Germany (1)
Proteome Dynamics MDC in the helmholtz association Berlin-Buch (1)
Principal Investigator „Stem Cell Metabolism“ Group Department of General Pediatrics, Neonatology, and Pediatric Cardiology University Clinic Düsseldorf (UKD), Heinrich Heine University (HHU) Moorenstraße 5, 40225 Düsseldorf, Germany Building 13.41, Level 3, Room 29 (1)
Oncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands (1)
federal university of rio de janeiro (1)
Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. (1)
Professor for Translational Epigenetics, Institute of Pathology, University Medical Center Germany (1)
Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA (1)
Laboratory of RNA Biology Institute of Molecular Genetics of the Czech Academy of Sciences Prague, Czechia (1)
Murdoch Children’s Research Institute, Melbourne (1)
McGill University Department of Pharmacology and Therapeutics Centre de Recherche en Biologie Structurale (1)
Assistant Professor of Neurology and Angela Dobson and Lyndon Welch Professor of Neurology Department of Neurology | University of Michigan Health System 109 Zina Pitcher Place, 5015 BSRB | Ann Arbor, MI | 48109 (1)
Bioanalytical Mass Spectrometry, Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149 Münster, Germany (1)
Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, 11521 Athens, Greece. (1)
Department of Experimental and Clinical Medicine, University of Catanzaro,Catanzaro (IT) (1)
Lund University, Dept. Biomedical Engineering (1)
Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands. (1)
Center for Network Systems Biology, Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA (1)
Department of Neuroscience University of Connecticut School of Medicine (1)
Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. (1)
Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany (1)
Deparetmento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. (1)
Cedars Sinai Medical Center (1)
Strand Leader BENM, Lloyd Sansom Chair Future Industries Institute, UniSA (1)
School of Life Sciences and Technology, Tongji University, Shanghai, China (1)
Department of General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich Heine University, Duesseldorf, Germany (1)

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pathogen (1)
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Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects

Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease of the hematopoietic system, which is caused by heterozygous mutations in RUNX1. FPD/AML patients have a bleeding disorder characterized by thrombocytopenia with reduced platelet numb...

ORGANISM(S): Homo sapiens

2014-07-01 | E-GEOD-54295 | biostudies-arrayexpress

Transcription profiling by array of human hepatic cells derived from foreskin fibroblast cell line and from embryonic stem cells.

Reprogrammed somatic cells offer a valuable source of pluripotent cells that have the potential to differentiate into many cells types and provide a new tool for regenerative medicine. In the present study we differentiated induced pluripotent stem cells (iPS cells) into hepatic cells. We first show...

ORGANISM(S): Homo sapiens

2009-08-07 | E-GEOD-14897 | biostudies-arrayexpress

Selective demethylation and altered gene expression are associated with ICF Syndrome in human induced pluripotent stem cells and mesenchymal stem cells

Immunodeficiency, Centromeric Instability, and Facial Anomalies Type I (ICF1) Syndrome is a rare genetic disease caused by mutations in DNMT3B, a de novo DNA methyltransferase. However, the molecular basis of how DNMT3B-deficiency leads to ICF1 pathogenesis is unclear. Induced pluripotent stem cell ...

ORGANISM(S): Homo sapiens

2014-11-17 | E-GEOD-46030 | biostudies-arrayexpress

Analysis of genomic integrity of disease corrected human induced pluripotent stem cells by exome sequencing

Induced pluripotent stem (iPS) cells hold great promise for autologous cell transplantation. In order to apply this therapy to monogenic disorder, disease-causing mutations must be corrected prior to transplantation. We generated iPS cells from patients with alpha-1 antitrypsin deficiency, which is ...

EGAS00001000055 | EGA

Human oocytes reprogram adult somatic cells to pluripotent stem cells [Illumina]

The stem cell lines were generated according to the principle described in Noggle et al., Nature 2011, Oct 5;478(7367):70-5. doi: 10.1038/nature10397. Title: Human oocytes reprogram somatic cells to a pluripotent state. Abstract: The exchange of the oocyte's genome with the genome of a somatic cel...

ORGANISM(S): Homo sapiens

2014-08-12 | E-GEOD-60360 | biostudies-arrayexpress

Generation of human induced pluripotent stem cells from mesenchymal cells of gut mesentery by Oct4/Sox2/Nanog

Background and aim: Human Induced pluripotent stem (iPS) cells have been derived from dermal ﬁbroblasts, keratinocytes and blood cells by ectopic expression of defined transcription factors.1–5 Application of this approach in human cells would have enormous potential and generate patient-specific pl...

ORGANISM(S): Homo sapiens

2009-09-26 | E-GEOD-18180 | biostudies-arrayexpress

Global gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells

Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPSC) obtained by reprogramming SMA patient and his healthy father fibroblasts, and gene...

ORGANISM(S): Homo sapiens

2013-01-04 | E-GEOD-27205 | biostudies-arrayexpress

Global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by corresponding fibroblasts

Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPS cells) obtained by reprogramming SMA patient and his healthy father fibroblasts, and...

ORGANISM(S): Homo sapiens

2013-01-04 | E-GEOD-27206 | biostudies-arrayexpress

Transcription profiling of mouse iPS cells from neural stem cells by 2 factors (Oct4, KLF4) (Kim, Zaehres et al.)

Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility to generate patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripo...

ORGANISM(S): Mus musculus

2008-10-20 | E-GEOD-10806 | biostudies-arrayexpress

Influence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells (Affymetrix expression)

Genome instability is a potential limitation to the research and therapeutic application of induced pluripotent stem cells (iPSCs). Observed genomic variations reflect the combined activities of DNA damage, cellular DNA damage response (DDR), and selection pressure in culture. To understand the cont...

ORGANISM(S): Homo sapiens

2016-03-29 | E-GEOD-78716 | biostudies-arrayexpress

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