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MetabolomicsUntargetted lipidomics dataset: LC-MS analysis in two postmortem brain areas of healthy individuals and schizophrenia patients.

Schizophrenia is a common mental illness. It is a complex disorder with many symptoms and cognitive impairments. Despite extensive study, the molecular mechanisms of this disease are still unknown. Present time studies on the lipid composition of the human brain are extremely fragmented. Of the p...

2024-06-04 | MTBLS8955 | MetaboLights
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
ModelsLi2016 - Model for pancreatic cancer patients receiving immunotherapy
immunotherapy offers a better prognosis for pancreatic cancer patients. As a direct extension of this work, various new therapy methods that are under exploration and clinical trials could be assessed or evaluated using the newly developed mathematical prognosis model.
2024-09-02 | BIOMD0000000929 | BioModels
ModelsTsur2019 - Response of patients with melanoma to immune checkpoint blockade
This is a simple mathematical population model for pembrolizumab-treated advanced melanoma patients, used to predict the response of melanoma patients to immune checkpoint inhibitors.
2024-09-02 | BIOMD0000000838 | BioModels
Immuno-oncology 
ModelsHuiyiLi2024 - Prediction of death risk in patients with acute diquat poisoning using Random Forest Model
The objective of this study was to develop and validate predictive models to assess the risk of death in patients with acute diquat (DQ) poisoning using innovative machine learning techniques. The study analyzed data from 201 consecutive patients admitted for deliberate oral intake of DQ between Feb...
2024-07-18 | MODEL2407180001 | BioModels
TranscriptomicsGene expression and epigenetic profiling of CD34+ hematopoietic progenitor cells in multiple sclerosis patients (expression)
Intense immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) is a potential treatment for patients suffering from aggressive multiple sclerosis (MS). However it remains unresolved whether autologous CD34+ hematopoietic progenitor cells of MS patients show gene exp...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-27688 | biostudies-arrayexpress
TranscriptomicsRNA-seq of synovial biopsies from rheumatoid arthritis patients
Synovial biopsies from rheumatoid arthritis patients were obtained and profiled using RNA-seq. Patients were stratified according to the number of swollen joints they had (SJC, swollen joint count) and divided in three groups for the differential expression analysis: None (SJC = 0), Low (1<= SJC <= ...
ORGANISM(S): Homo sapiens 
2021-04-26 | E-MTAB-6684 | biostudies-arrayexpress
GenomicsClostridioides difficile strain:Hospitalized patients | isolate:Hospitalized patients
Clostridioides difficile strain:Hospitalized patients | isolate:Hospitalized patients Genome sequencing and assembly
PRJNA732612 | ENA
ProteomicsIgG from systemic sclerosis patients induce a profibrosing and serotype-dependent phenotype in normal dermal fibroblast: a multi-omics study
Autoantibodies (Aab) are frequent in systemic sclerosis (SSc). While recognized as potent biomarkers, their pathogenic role is much debated. This study explored the effect of purified IgG from SSc patients on the phenotype and function of healthy dermal fibroblast (FB) using an innovative multi-omic...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD025885 | Pride
Autoantibodies Sensitive proteomic Systemic sclerosis Multi-omics analysis Anti-topoisomerase type i 
ProteomicsProteomic analysis of serum samples of paracoccidioidomycosis patients with severe pulmonary sequel
Pulmonary sequelae (PS) in patients with chronic paracoccidioidomycosis (PCM) typically include pulmonary fibrosis and emphysema. Knowledge of the molecular pathways involved in PS of PCM is required for treatment and biomarker identification. This non-concurrent cohort study included 29 patients wi...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD026906 | Pride
Molecular analysis Pulmonary fibrosis Paracoccidioides brasiliensis 
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