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ProteomicsTrait tacking for predictive evolution of metabolic pheotypes
Adaptive laboratory evolution is highly effective for improving desired traits through natural selection. However, its applicability is inherently constrained to growth-correlated traits precluding traits of interest that incur a fitness cost, such as metabolite secretion. Here, we introduce the con...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-07-12 | PXD023171 | Pride
Ale s. cerevisiae wine aroma 
ModelsMontagud2010 - Genome-scale metabolic network of Synechocystis sp. PCC6803 (iSyn669)
Montagud2010 - Genome-scale metabolic network of Synechocystis sp. PCC6803 (iSyn669) This model is described in the article: Reconstruction and analysis of genome-scale metabolic model of a photosynthetic bacterium. Montagud A, Navarro E, Fernández de Córdoba P, Urchueguía J...
2015-07-30 | MODEL1507180008 | BioModels
ProteomicsUnravelling metabolic cross-feeding in a yeast-bacteria community using 13C proteomics
Cross-feeding is fundamental to the diversity and function of microbial communities. However, identification of cross-fed metabolites is often challenging due to the universality of metabolic and biosynthetic intermediates. Here, we use 13C isotope tracing in peptides to elucidate cross-fed metaboli...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-07 | PXD019952 | Pride
Protein stable-isotope labeling (protein-sip) Cross-feeding Synthetic community : microbial interaction 
ProteomicsAdaptive Laboratory Evolution of microbial co-cultures for improved metabolite secretion
Small microbial mutualistic communities consisting of lactic acid bateria and S. cerevisiae evolved together for increased vitamin secretion from the lactic acid bacteria. Proteomics analysis of the parental and evolved bacteria to identify differences that occured during the prolonged co-evolution.
ORGANISM(S): Lactobacillus plantarum 
2021-08-05 | PXD022250 | Pride
Vitamins Ale Lactic acid bacteria Co-evolution 
ProteomicsOperation of a TCA cycle subnetwork in the mammalian nucleus_mass4tox
Nucleic acid and histone modifications critically depend on central metabolism for substrates and co-factors. Although a few enzymes related to the formation of these required metabolites have been reported in the nucleus, the corresponding metabolic pathways are considered to function elsewhere in ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032238 | Pride
Tricarboxylic acid (tca) cycle Nuclear proteins Non canonical metabolism compartmentalization Gene expression regulation 
ProteomicsOperation of a TCA cycle subnetwork in the mammalian nucleus
Nucleic acid and histone modifications critically depend on central metabolism for substrates and co-factors. Although a few enzymes related to the formation of these metabolites have been reported in the nucleus, the corresponding metabolic pathways are considered to function elsewhere in the cell....
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD022608 | Pride
Nucleus Metabolic pathways Proximity-biotinylation mass spectrometry Stable isotope metabolomics study 
MetabolomicsAdaptive laboratory evolution of microbial co-cultures for improved metabolite secretion

Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization. Here, we introduce coevolution of obligatory mutuali...

2021-07-02 | MTBLS2217 | MetaboLights
MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
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