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ProteomicsFunctional characterization of Phosphoenolpyruvate Carboxykinase 2 in Group 3 Medulloblastoma using Mass Spectrometry
Group 3 medulloblastoma (G3 MB) is an aggressive pediatric brain tumor subtype associated with poor prognosis and high metastasis, comprising about 20–25% of cases. G3 MB commonly features MYC amplification, which drives oncogenic transcription, enhanced biosynthesis, and metabolic rewiring to sup...
ORGANISM(S): Homo Sapiens (human) 
2026-05-06 | PXD070897 | JPOST Repository
ProteomicsProteomic profiling of nuclear fractions of SMARCA4 knockdown samples in HDMB03
SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. Nuclear enrichment was performed using hypertonic and ...
ORGANISM(S): Homo Sapiens (human) 
2026-03-25 | PXD070641 | JPOST Repository
ProteomicsProteomic profiling of in vitro knockdown of SMARCA4 in Medulloblastoma
SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. We performed both DDA and DIA analyses and found that ...
ORGANISM(S): Homo Sapiens (human) 
2026-03-25 | PXD070640 | JPOST Repository
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