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ProteomicsTarget deconvolution in Plasmodium falciparum using pulldowns
Parasite lysates were centrifuged (20,000 g, 4°C, 15 min). Beads (blank and with linker attached) were washed 3× with water then twice with lysis buffer. The lysate (~2 mg total protein) was first incubated with 2 mg blank beads for 30 min at 4°C with rotating agitation. The lysate was divided into ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-10-15 | PXD033740 | Pride
Pulldown Plasmodium falciparum Drug target Chemical proteomics 
UnknownPreventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial.
Not available
S-EPMC11520224 | biostudies-literature
ProteomicsMultiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
Samples were reduced by the addition of TCEP (25 mM final concentration) and incubated at 37 ºC for 10 min. Alkylation was carried out by the addition of iodoacetamide (25 mM final concentration) and incubated at RT for 1 h in the dark. Samples were then digested by the addition of 1:50 LysC (Wako, ...
ORGANISM(S): Leishmania donovani BPK282A1 
2021-07-18 | PXD023780 | Pride
Thermal proteome profiling Leishmania Oxidosqualene synthase 
UnknownMultiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Not available
S-EPMC8153249 | biostudies-literature
ProteomicsDrug target deconvolution in Plasmodium falciparum using thermal proteomics profiling
Early identification of a compound’s mode of action can greatly benefit the discovery process. Thermal proteomics profiling (TPP) is a powerful, unbiased tool that can be used to identify potential ligands of protein targets. TPP takes advantage of the fact that a ligand binding to its target prot...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-10-13 | PXD025182 | Pride
Lysine trna synthetase Thermal proteome profiling Plasmodium falciparum 
UnknownA survey by the European Society of Breast Imaging on the implementation of breast diffusion-weighted imaging in clinical practice.
Not available
S-EPMC9064723 | biostudies-literature
UnknownDevelopment of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Not available
S-EPMC10350920 | biostudies-literature
UnknownDNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Not available
S-EPMC8591608 | biostudies-literature
UnknownTrial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
Not available
S-EPMC9134321 | biostudies-literature
UnknownHyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients.
Not available
S-EPMC7612070 | biostudies-literature
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